(2S,1'R,2'S)-2-(2-羧基环丙基)甘氨酸
(2S,1'R,2'S)-2-(2-羧基环丙基)甘氨酸结构式
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常用名 | (2S,1'R,2'S)-2-(2-羧基环丙基)甘氨酸 | 英文名 | L-CCG-IV |
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| CAS号 | 117857-95-1 | 分子量 | 159.14000 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C6H9NO4 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Binding and transport of [3H](2S,4R)- 4-methylglutamate, a new ligand for glutamate transporters, demonstrate labeling of EAAT1 in cultured murine astrocytes.
J. Neurosci. Res. 75(6) , 751-9, (2004) Transporters for L-glutamate (excitatory amino acid transporters; EAATs), localized to astrocytes, are involved intimately in intermediary metabolism within the brain. Because (2S,4R)-4-methylglutamate (4MG) has affinity for glial EAATs, we employed [(3)H]4MG... |
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Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs.
J. Med. Chem. 50 , 4630-41, (2007) Bioisosteric replacements of the distal acidic group of L-glutamic acid (L-Glu, 1) and conformational constraining of its carbon skeleton, have been widely exploited to discover competitive modulators of glutamate receptors. Noteworthy, L-homocysteic acid (L-... |
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Involvement of Group II mGluRs in mossy fiber LTD.
Synapse 63(12) , 1060-8, (2009) Mossy fiber long-term depression (LTD) has been shown to be triggered by either pharmacological or synaptic activation of Group II metabotropic glutamate receptors (mGluRs) whereas other studies indicate that synaptic activation of mGluRs is very limited. The... |
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Behavioral evidence supporting a differential role for spinal group I and II metabotropic glutamate receptors in inflammatory hyperalgesia in sheep.
Neuropharmacology 43(3) , 319-26, (2002) A differential role for metabotropic glutamate receptors (mGluRs) in spinal nociception in normal animals has previously been identified. The present study examined the contribution of group I and group II mGluRs to the development and maintenance of inflamma... |
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Enantioselective Synthesis of L-CCG-I.
J. Org. Chem. 68(17) , 6817-9, (2003) Introduction of natural menthol as the chiral auxiliary in a gamma-Br-alpha,beta-unsaturated ester leads to enantioselective generation of three chiral centers in a single step on reaction with a glycine anion equivalent to provide L-CCG-I in 94% ee. |
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Enantio- and diastereocontrolled conversion of chiral epoxides to trans-cyclopropane carboxylates: application to the synthesis of cascarillic acid, grenadamide and L-(-)-CCG-II.
Org. Biomol. Chem. 10(34) , 6987-94, (2012) An efficient high yielding improved method for the enantio- and diastereoselective cyclopropanation of chiral epoxides using triethylphosphonoacetate and base (Wadsworth-Emmons cyclopropanation) is reported. The utility of this protocol is illustrated by conc... |
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Metabotropic glutamate receptor mGlu2 is resistant to homologous agonist-induced desensitization but undergoes protein kinase C-mediated heterologous desensitization.
Eur. J. Pharmacol. 649(1-3) , 29-37, (2010) To investigate the susceptibility of the group II metabotropic glutamate receptor mGlu2 to agonist-induced desensitization, the receptor was stably expressed in Chinese hamster ovary (CHO-mGlu2) or C6 glioma cells (C6-mGlu2). Exposure of CHO-mGlu2 cells to th... |
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Group II metabotropic glutamate receptors depress synaptic transmission onto subicular burst firing neurons.
PLoS ONE 7(9) , e45039, (2012) The subiculum (SUB) is a pivotal structure positioned between the hippocampus proper and various cortical and subcortical areas. Despite the growing body of anatomical and intrinsic electrophysiological data of subicular neurons, modulation of synaptic transm... |
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Chronic exposure to ammonia alters the modulation of phosphorylation of microtubule-associated protein 2 by metabotropic glutamate receptors 1 and 5 in cerebellar neurons in culture.
Neuroscience 133(1) , 185-91, (2005) Hyperammonemia impairs signal transduction associated to glutamate receptors and phosphorylation of some neuronal proteins including microtubule-associated protein 2 (MAP-2). The aim of this work was to analyze the effects of hyperammonemia on modulation of M... |
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Anxiolytic action of group II and III metabotropic glutamate receptors agonists involves neuropeptide Y in the amygdala.
Pharmacol. Rep. 57(6) , 734-43, (2005) Several lines of evidence indicate that activation of group II and III metabotropic glutamate (mGlu) receptors produces anxiolytic-like effects in rodents. On the other hand neuropeptide Y (NPY) induces an anxiolytic effect in rats after intraventricular or i... |