Organic & Biomolecular Chemistry 2012-09-14

Enantio- and diastereocontrolled conversion of chiral epoxides to trans-cyclopropane carboxylates: application to the synthesis of cascarillic acid, grenadamide and L-(-)-CCG-II.

Pradeep Kumar, Abhishek Dubey, Anand Harbindu

文献索引：Org. Biomol. Chem. 10(34) , 6987-94, (2012)

摘要

An efficient high yielding improved method for the enantio- and diastereoselective cyclopropanation of chiral epoxides using triethylphosphonoacetate and base (Wadsworth-Emmons cyclopropanation) is reported. The utility of this protocol is illustrated by concise and practical synthesis of cascarillic acid, grenadamide and L-(-)-CCG-II, a cyclopropane containing natural products.

结构式	名称/CAS号	分子式	全部文献
	(2S,1'R,2'S)-2-(2-羧基环丙基)甘氨酸 CAS:117857-95-1	C₆H₉NO₄

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Enantio- and diastereocontrolled conversion of chiral epoxides to trans-cyclopropane carboxylates: application to the synthesis of cascarillic acid, grenadamide and L-(-)-CCG-II.

摘要

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