烟酰胺
烟酰胺结构式
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常用名 | 烟酰胺 | 英文名 | Nicotinamide |
|---|---|---|---|---|
| CAS号 | 98-92-0 | 分子量 | 122.125 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 257.7±32.0 °C at 760 mmHg | |
| 分子式 | C6H6N2O | 熔点 | 128-131 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 109.7±25.1 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth.
PLoS Biol. 12(1) , e1001758, (2014) Type III interferon (IFN-λ) exhibits potent antiviral activity similar to IFN-α/β, but in contrast to the ubiquitous expression of the IFN-α/β receptor, the IFN-λ receptor is restricted to cells of epithelial origin. Despite the importance of IFN-λ in tissue-... |
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Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells.
Drug Des. Devel. Ther. 9 , 425-64, (2015) Ovarian cancer is a leading killer of women, and no cure for advanced ovarian cancer is available. Alisertib (ALS), a selective Aurora kinase A (AURKA) inhibitor, has shown potent anticancer effects, and is under clinical investigation for the treatment of ad... |
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Functionalized tetrahydro-1H-pyrido[4,3-b]indoles: a novel chemotype with Sirtuin 2 inhibitory activity.
Eur. J. Med. Chem. 92 , 145-55, (2015) Sirtuins are protein deacylases with regulatory roles in metabolism and stress response. Functionalized tetrahydro-1H-pyrido[4,3-b]indoles were identified as preferential sirtuin 2 inhibitors, with in vitro inhibitory potencies in the low micromolar concentra... |
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Identification and characterization of epithelial cells derived from human ovarian follicular fluid.
Stem Cell Res. Ther. 6 , 13, (2015) Follicular fluid is important for follicular development and oocyte maturation. Evidence suggests that follicular fluid is not only rich in proteins but cells. Besides oocytes, the follicular fluid contains granulosa, thecal, and ovarian surface epithelial ce... |
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An innovative oat-based sterile emollient cream in the maintenance therapy of childhood atopic dermatitis.
Pediatr. Dermatol. 32(2) , 208-15, (2015) Although emollients are recommended in the management of atopic dermatitis (AD), regimens for emollient maintenance therapy are awaiting validation. We conducted an international, multicenter, open-label trial to assess the effects of a 3-month maintenance tr... |
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Hypoglycemic, antihyperglycemic, and antioxidant effects of the edible plant Anoda cristata.
J. Ethnopharmacol. 161 , 36-45, (2015) Some studies refer that the entire plant of Anoda cristata is consumed as food and medicine; in particular for treating diabetes, inflammation, fever, cough, and wounds. The aim of this study was to establish the preclinical efficacy of Anoda cristata as hypo... |
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Tissue vitamin concentrations are maintained constant by changing the urinary excretion rate of vitamins in rats' restricted food intake.
Biosci. Biotechnol. Biochem. 78(12) , 2102-9, (2014) We previously reported that mild food restriction induces a reduction in tryptophan-nicotinamide conversion, which helps to explain why death secondary to pellagra is pandemic during the hungry season. In this study, we investigated the levels of B-group vita... |
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Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1.
Biochem. Pharmacol. 90(4) , 367-78, (2014) Cancer cells often become resistant to chemotherapy through a phenomenon known as multidrug resistance (MDR). Several factors are responsible for the development of MDR, preeminent among them being the accelerated drug efflux mediated by overexpression of ATP... |
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Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1.
Basic Res. Cardiol. 110 , 37, (2015) Hypoadiponectinemia is an independent predictor of cardiovascular disease, impairs mitochondrial function in skeletal muscle, and has been linked to the pathogenesis of Type 2 diabetes. In models of Type 2 diabetes, myocardial mitochondrial function is impair... |
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Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation.
Proc. Natl. Acad. Sci. U. S. A. 111(48) , 17116-21, (2014) In the fasted state, increases in catecholamine signaling promote adipocyte function via the protein kinase A-mediated phosphorylation of cyclic AMP response element binding protein (CREB). CREB activity is further up-regulated in obesity, despite reductions ... |