Nicotinamide

Modify Date: 2024-01-01 18:46:46

Nicotinamide structure	Common Name	Nicotinamide
	CAS Number	98-92-0	Molecular Weight	122.125
	Density	1.2±0.1 g/cm3	Boiling Point	257.7±32.0 °C at 760 mmHg
	Molecular Formula	C₆H₆N₂O	Melting Point	128-131 °C(lit.)
	MSDS	Chinese USA	Flash Point	109.7±25.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of Nicotinamide

Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.

Name	3-Pyridinecarboxamide
Synonym	More Synonyms

Description	Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Neurological Disease Natural Products >> Others
Target	PARP-1 Human Endogenous Metabolite
In Vitro	Pretreatment with the poly (ADP-ribose) polymerase (PARP) inhibitor nicotinamide is able to prevent HCN2 cell death. When nicotinamide is added prior to t-BuOOH, it is able to prevent neuronal cell death and inhibit apoptosis. Nicotinamide-pretreated neurons have higher expression levels of inhibitors of apoptosis (IAP) genes[1]. Nicotinamide inhibits vasoconstriction by ET. Nicotinamide also alleviates oxidative stress, which exacerbates PE and FGR[3].
In Vivo	Normal and streptozotocin-nicotinamide induced adult male diabetic rats receive quercetin (10, 25 and 50 mg/kg/bw) orally, and cause significant decrease in FBG and cardiac injury marker levels with increased in insulin levels[2]. Nicotinamide improves maternal hypertension, proteinuria, and glomerular endotheliosis in RUPP mice. Moreover, nicotinamide prolongs pregnancies, and improves survival and growth of the embryos in RUPP PE mice[3].
Animal Admin	DM is induced via a single intraperitoneal (i.p) injection of nicotinamide (110 mg/kg/body weight) dissolved in normal saline 15 min prior to streptozotocin (STZ) (55 mg/kg/body weight) injection, which is dissolved in a freshly prepared 0.1mol/Lcitrate buffer (pH 4.5). These injections are given following an overnight fast. Control rats (n=6) are injected with the same amount of solvent. In order to prevent hypoglycemia in the first 24 h following STZ injection, rats are allowed to have free access to water with 5% dextrose (D5W). Three days after STZ-nicotinamide injection, rats with FBG levels greater than 7.0 mM are considered as diabetic.
References	[1]. Bhansali SG, et al. Nicotinamide prevents apoptosis in human cortical neuronal cells. Toxicol Mech Methods. 2006;16(4):173-80. [2]. Roslan J, et al. Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats. Biomed Pharmacother. 2016 Dec 24;86:570-582 [3]. Fushima T, et al. Nicotinamide ameliorates a preeclampsia-like condition in mice with reduced uterine perfusion pressure. Am J Physiol Renal Physiol. 2016 Dec 7:ajprenal.00501.2016 [4]. Suzuki E, et al. Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake. Life Sci. 2010 Apr 24;86(17-18):676-82.

Density	1.2±0.1 g/cm3
Boiling Point	257.7±32.0 °C at 760 mmHg
Melting Point	128-131 °C(lit.)
Molecular Formula	C₆H₆N₂O
Molecular Weight	122.125
Flash Point	109.7±25.1 °C
Exact Mass	122.048012
PSA	55.98000
LogP	-0.24
Appearance of Characters	powder \| white
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.590
Storage condition	0-6°C
Stability	Stable. Incompatible with strong oxidizing agents.
Water Solubility	1000 g/L (20 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QS3675000

CHEMICAL NAME :: Nicotinamide

CAS REGISTRY NUMBER :: 98-92-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C6-H6-N2-O

MOLECULAR WEIGHT :: 122.14

WISWESSER LINE NOTATION :: T6NJ CVZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1680 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2050 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 5 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 126,63,1984 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0321 No. of Facilities: 1142 (estimated) No. of Industries: 6 No. of Occupations: 15 No. of Employees: 17336 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0321 No. of Facilities: 2791 (estimated) No. of Industries: 8 No. of Occupations: 34 No. of Employees: 64950 (estimated) No. of Female Employees: 44524 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26;S36
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	QS3675000
HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Niacinamide

MFCD00006395

Nicotinic acid amide

Vitamin- B3

Witamina PP

3-Pyridinecarboxamide

Nicotinamide

Pyridine-3-carboxamide

T6NJ CVZ

Dipigyl

EINECS 202-713-4

Vi-noctyl

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Nicotinamide

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