6-硝基联苯
6-硝基联苯结构式
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常用名 | 6-硝基联苯 | 英文名 | Chrysene, 6-nitro- |
|---|---|---|---|---|
| CAS号 | 7496-02-8 | 分子量 | 273.28500 | |
| 密度 | 1.342g/cm3 | 沸点 | 505ºC at 760 mmHg | |
| 分子式 | C18H11NO2 | 熔点 | 220ºC (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 252.5ºC | |
| 符号 |
GHS07, GHS08 |
信号词 | Danger |
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Polycyclic nitroarenes (nitro-PAHs) as biomarkers of exposure to diesel exhaust.
Mutat. Res. 441(1) , 135-44, (1999) Diesel exhaust contains numerous genotoxic carcinogens. It is essentially unknown to which extent this source contributes to the total load of these chemicals in humans. One possible approach to the problem is to find suitable biomarkers. To this end five pol... |
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Synthesis of anti-1,2-dihydroxy-3,4-epoxy-1,2,3, 4-tetrahydro-6-nitrochrysene and its reaction with 2'-deoxyguanosine- 5'-monophosphate, 2'-deoxyadenosine-5'-monophosphate, and calf thymus DNA in vitro.
Chem. Res. Toxicol. 13(11) , 1143-8, (2000) The remarkable carcinogenic activity of 6-nitrochrysene (6-NC) in several animal models, and its environmental presence, suggest its potential importance with regard to human cancer development. Depending on the bioassay model, 6-NC can be activated by simple... |
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Genomic DNA sequencing of mRNA splicing mutants in the hprt gene of Chinese hamster ovary cells.
Environ. Mol. Mutagen. 25(2) , 85-96, (1995) We have analyzed 41 mRNA-splicing mutants from the hypoxanthine-guanine phosphoribosyl-transferase (hprt) gene of Chinese hamster ovary (CHO) cells. Twenty-two of these mutants produced single cDNA PCR products with a partial or complete exon deletion; 19 mut... |
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Fungal biotransformation of 6-nitrochrysene.
Appl. Environ. Microbiol. 64(8) , 3106-9, (1998) The fungus Cunninghamella elegans was used to biotransform 6-nitrochrysene, a mutagen that is a widespread environmental contaminant. After 6 days, 74% of the 3H-labeled 6-nitrochrysene added had been metabolized to two isomeric sulfate conjugates. These conj... |
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Inefficient nucleotide excision repair in human cell extracts of the N-(deoxyguanosin-8-yl)-6-aminochrysene and 5-(deoxyguanosin-N(2)-yl)-6-aminochrysene adducts derived from 6-nitrochrysene.
Chem. Res. Toxicol. 24(1) , 65-72, (2011) Ubiquitous environmental agents [e.g., polynuclear aromatic hydrocarbons (PAHs) and their nitrated derivatives (NO(2)-PAHs)] that are known to induce mammary cancer in rodents are regarded as potential human risk factors for inducing analogous human cancers. ... |
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Stereoselective metabolism of the environmental mammary carcinogen 6-nitrochrysene to trans-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene by aroclor 1254-treated rat liver microsomes and their comparative mutation profiles in a laci mammary epithelial cell line.
Chem. Res. Toxicol. 22(12) , 1992-7, (2009) The environmental pollutant 6-nitrochrysene (6-NC) is a powerful mammary carcinogen and mutagen in rats. Our previous studies have shown that 6-NC is metabolized to trans-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene (1,2-DHD-6-NC) in rats and in several in vitro... |
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Mammary carcinogenesis and molecular analysis of in vivo cII gene mutations in the mammary tissue of female transgenic rats treated with the environmental pollutant 6-nitrochrysene.
Carcinogenesis 25(4) , 637-43, (2004) We determined the mutant fractions (MF) and mutational specificities in the cII gene in histologically confirmed normal, non-involved and tumor mammary tissues of female transgenic (Big Blue F344 x Sprague-Dawley)F1 rats treated with the environmental polluta... |
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Metabolism and DNA binding of the environmental pollutant 6-nitrochrysene in primary culture of human breast cells and in cultured MCF-10A, MCF-7 and MDA-MB-435s cell lines.
Int. J. Cancer 100(4) , 395-400, (2002) The environmental pollutant 6-nitrochrysene (6-NC) is a potent mammary carcinogen in the rat. To determine if the results obtained in 6-NC-treated rodents can be applicable to humans, we examined its metabolic activation in primary cultures of human breast ce... |
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Comparative mutational profiles of the environmental mammary carcinogen, 6-nitrochrysene and its metabolites in a lacI mammary epithelial cell line.
Carcinogenesis 28(11) , 2391-7, (2007) The dietary and environmental agent, 6-nitrochrysene (6-NC) is a powerful mammary carcinogen and mutagen in rats. It is known to be metabolized by ring-oxidation, nitro-reduction and a combination of the two pathways. In order to determine the ultimate mutage... |
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Dietary restriction modulated carcinogen-DNA adduct formation and the carcinogen-induced DNA strand breaks.
Toxicol. Lett. 92(1) , 21-30, (1997) Dietary restriction (DR) alters the activities of hepatic drug metabolizing enzymes and modulates the formation of carcinogen-DNA adducts in carcinogen treated animals. Our previous results showed that a 40% restriction of diet (60% of ad libitum (AL) food co... |