Chrysene, 6-nitro-

Modify Date: 2024-01-06 07:16:45

Chrysene, 6-nitro- Structure
Chrysene, 6-nitro- structure
Common Name Chrysene, 6-nitro-
CAS Number 7496-02-8 Molecular Weight 273.28500
Density 1.342g/cm3 Boiling Point 505ºC at 760 mmHg
Molecular Formula C18H11NO2 Melting Point 220ºC (dec.)(lit.)
MSDS Chinese USA Flash Point 252.5ºC
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger

 Names

Name 6-Nitrochrysene
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.342g/cm3
Boiling Point 505ºC at 760 mmHg
Melting Point 220ºC (dec.)(lit.)
Molecular Formula C18H11NO2
Molecular Weight 273.28500
Flash Point 252.5ºC
Exact Mass 273.07900
PSA 45.82000
LogP 5.57760
Index of Refraction 1.791
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GC1930000
CHEMICAL NAME :
Chrysene, 6-nitro-
CAS REGISTRY NUMBER :
7496-02-8
BEILSTEIN REFERENCE NO. :
2134652
LAST UPDATED :
199612
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C18-H11-N-O2
MOLECULAR WEIGHT :
273.30
WISWESSER LINE NOTATION :
L E6 B666J DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9163 ug/kg/2W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
Micronucleus test

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 279,153,1992 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,267,1989 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,267,1989 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,267,1989

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger
Hazard Statements H302 + H312 + H332-H340-H350
Precautionary Statements P201-P261-P280-P301 + P312 + P330-P308 + P313
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T
Risk Phrases 45-46-20/21/22
Safety Phrases S22;S45;S53;S36/S37/S39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS GC1930000

 Articles27

More Articles
Polycyclic nitroarenes (nitro-PAHs) as biomarkers of exposure to diesel exhaust.

Mutat. Res. 441(1) , 135-44, (1999)

Diesel exhaust contains numerous genotoxic carcinogens. It is essentially unknown to which extent this source contributes to the total load of these chemicals in humans. One possible approach to the p...

Synthesis of anti-1,2-dihydroxy-3,4-epoxy-1,2,3, 4-tetrahydro-6-nitrochrysene and its reaction with 2'-deoxyguanosine- 5'-monophosphate, 2'-deoxyadenosine-5'-monophosphate, and calf thymus DNA in vitro.

Chem. Res. Toxicol. 13(11) , 1143-8, (2000)

The remarkable carcinogenic activity of 6-nitrochrysene (6-NC) in several animal models, and its environmental presence, suggest its potential importance with regard to human cancer development. Depen...

Genomic DNA sequencing of mRNA splicing mutants in the hprt gene of Chinese hamster ovary cells.

Environ. Mol. Mutagen. 25(2) , 85-96, (1995)

We have analyzed 41 mRNA-splicing mutants from the hypoxanthine-guanine phosphoribosyl-transferase (hprt) gene of Chinese hamster ovary (CHO) cells. Twenty-two of these mutants produced single cDNA PC...

 Synonyms

6-nitrochrysene
MFCD00021179