Chrysene, 6-nitro-
Names
Chemical & Physical Properties
[ Density]:
1.342g/cm3
[ Boiling Point ]:
505ºC at 760 mmHg
[ Melting Point ]:
220ºC (dec.)(lit.)
[ Molecular Formula ]:
C18H11NO2
[ Molecular Weight ]:
273.28500
[ Flash Point ]:
252.5ºC
[ Exact Mass ]:
273.07900
[ PSA ]:
45.82000
[ LogP ]:
5.57760
[ Index of Refraction ]:
1.791
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GC1930000
- CHEMICAL NAME :
- Chrysene, 6-nitro-
- CAS REGISTRY NUMBER :
- 7496-02-8
- BEILSTEIN REFERENCE NO. :
- 2134652
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C18-H11-N-O2
- MOLECULAR WEIGHT :
- 273.30
- WISWESSER LINE NOTATION :
- L E6 B666J DNW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 9163 ug/kg/2W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 279,153,1992 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,267,1989 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,267,1989 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,267,1989
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302 + H312 + H332-H340-H350
[ Precautionary Statements ]:
P201-P261-P280-P301 + P312 + P330-P308 + P313
[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T
[ Risk Phrases ]:
45-46-20/21/22
[ Safety Phrases ]:
S22;S45;S53;S36/S37/S39
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
GC1930000
Precursor & DownStream
Precursor
DownStream
Articles
Mutat. Res. 441(1) , 135-44, (1999)
Diesel exhaust contains numerous genotoxic carcinogens. It is essentially unknown to which extent this source contributes to the total load of these chemicals in humans. One possible approach to the p...
Synthesis of anti-1,2-dihydroxy-3,4-epoxy-1,2,3, 4-tetrahydro-6-nitrochrysene and its reaction with 2'-deoxyguanosine- 5'-monophosphate, 2'-deoxyadenosine-5'-monophosphate, and calf thymus DNA in vitro.Chem. Res. Toxicol. 13(11) , 1143-8, (2000)
The remarkable carcinogenic activity of 6-nitrochrysene (6-NC) in several animal models, and its environmental presence, suggest its potential importance with regard to human cancer development. Depen...
Genomic DNA sequencing of mRNA splicing mutants in the hprt gene of Chinese hamster ovary cells.Environ. Mol. Mutagen. 25(2) , 85-96, (1995)
We have analyzed 41 mRNA-splicing mutants from the hypoxanthine-guanine phosphoribosyl-transferase (hprt) gene of Chinese hamster ovary (CHO) cells. Twenty-two of these mutants produced single cDNA PC...