六氟丙酮三水合物
六氟丙酮三水合物结构式
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常用名 | 六氟丙酮三水合物 | 英文名 | Hexafluoroacetone trihydrate |
|---|---|---|---|---|
| CAS号 | 34202-69-2 | 分子量 | 220.068 | |
| 密度 | 1.579 g/mL at 25 °C(lit.) | 沸点 | 106-108 °C | |
| 分子式 | C3H6F6O4 | 熔点 | 18-21 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 105-106°C | |
| 符号 |
GHS05, GHS06, GHS08 |
信号词 | Danger |
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Amidinate salt of hexafluoroacetone hydrate for the preparation of fluorinated compounds by the release of trifluoroacetate.
Org. Lett. 15(1) , 208-11, (2013) A powerful, new reagent, an amidinate salt of hexafluoroacetone hydrate, is an air-stable salt that can be used for the preparation of fluorinated organic molecules. Nucleophilic trifluoromethylation reactions are demonstrated following the base-promoted rele... |
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Conformational landscape of N-glycosylated peptides detecting autoantibodies in multiple sclerosis, revealed by Hamiltonian replica exchange.
J. Phys. Chem. B 116(18) , 5458-67, (2012) Synthetic N-glycosylated CSF114(Glc) and related peptides were proved to be able to recognize specific and high-affinity autoantibodies circulating in blood of relapsing-remitting multiple sclerosis (MS) patients and correlating with disease activity. The eff... |
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Synthetic interface peptides as inactivators of multimeric enzymes: inhibitory and conformational properties of three fragments from Lactobacillus casei thymidylate synthase.
Biochemistry 37(19) , 6883-93, (1998) Three synthetic peptides corresponding to distinct segments of the subunit interface of the dimeric enzyme thymidylate synthase (residues 17-38, N 22; residues 174-190, M 17; and residues 201-220, C 20) have been investigated for their ability to function as ... |
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Hexafluoroacetone hydrate as a structure modifier in proteins: characterization of a molten globule state of hen egg-white lysozyme.
Protein Sci. 6(5) , 1065-73, (1997) A molten globule-like state of hen egg-white lysozyme has been characterized in 25% aqueous hexafluoroacetone hydrate (HFA) by CD, fluorescence, NMR, and H/D exchange experiments. The far UV CD spectra of lysozyme in 25% HFA supports retention of native-like ... |
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Conformational equilibria in formic acid and the adduct of formic acid and hexafluoroacetone, HCO2C(CF3)2OH.
J. Org. Chem. 72(6) , 2003-7, (2007) Low-temperature 1H and 13C NMR spectra of formic acid (1) showed separate signals for the E and Z conformations in solvents containing a hydrogen bond acceptor, dimethyl ether. The population of E-1 (6.2% in 3:1:1 CHClF2/CHCl2F/(CH3)2O) was larger than that f... |
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Synthesis and biological evaluations of C-23-modified 26,26,26,27,27,27-F6-vitamin D3 analogues.
Bioorg. Med. Chem. 8(7) , 1809-17, (2000) A convenient synthetic method which could allow flexible modification at C-23 of 26,26,26,27,27,27-hexafluoro-1alpha,25-dihydroxyvitamin D3 (3) has been developed. An effective construction of hexafluoroacetone (HFA) aldol part on the side chain of 10 was ach... |
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Biotransformation of the aerosol propellant 1,1,1,2,3,3,3-heptafluoropropane (HFA-227): lack of protein binding of the metabolite hexafluoroacetone.
Drug Metab. Dispos. 24(8) , 906-10, (1996) The biotransformation of the aerosol propellant 1,1,1,2,3,3,3-heptafluoropropane (HFA-227) was investigated in rats in vivo and in rat and human liver microsomes. In the urine of rats exposed to 5000 ppm HFA-227 for 6 hr, very small amounts of hexafluoroaceto... |
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Structure and solvation of melittin in hexafluoroacetone/water.
Biopolymers 74(3) , 240-7, (2004) Intermolecular (1)H[(19)F] and (1)H[(1)H] nuclear Overhauser effects have been used to explore interaction of solvent components with melittin dissolved in 50% hexafluoroacetone trihydrate (HFA)/water. Standard nuclear Overhauser effect experiments and an ana... |
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A new protection/activation strategy for the synthesis of naturally occurring and non-natural alpha-N-alkylamino acids.
Amino Acids 16(3-4) , 287-95, (1999) A new method for the preparation of N-methylamino acids and some of their derivatives starting from hexafluoroacetone protected amino acids is described. The new concept results in saving of steps compared to conventional protection/activation techniques. Pro... |
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Hexafluoroacetone as protecting and activating reagent: site-selective functionalization of iminodiacetic acid.
Amino Acids 27(3-4) , 285-90, (2004) Hexafluoroacetone was applied as a bidentate protecting and activating agent for the syntheses of RGD-peptide mimetics starting from iminodiacetic acid in solution and on solid phase. |