(-)-双甲基溴甲烷
(-)-双甲基溴甲烷结构式
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常用名 | (-)-双甲基溴甲烷 | 英文名 | (-)-BICUCULLINE METHBROMIDE |
|---|---|---|---|---|
| CAS号 | 66016-70-4 | 分子量 | 462.29100 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C21H20BrNO6 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS06, GHS09 |
信号词 | Danger |
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Correlated changes in NMDA receptor phosphorylation, functional activity, and sedation by chronic ethanol consumption.
J. Neurochem. 115(5) , 1112-22, (2010) Alcohol abuse leads to tolerance, dependence, and memory impairments that involve excitatory glutamatergic NMDA synaptic transmission. The NMDA receptor (NMDAR) is known to undergo activity-dependent adaptive functional changes. Since we observed that acute e... |
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Further characterization of the anorexic action of orally-administered THIP, a GABA-analogue, in the rat.
Physiol. Behav. 29(5) , 901-4, (1982) Sprague-Dawley rats were used to further characterize the anorexic action of orally-administered THIP, a GABA-analogue. The anorexic action of THIP (5 or 10 mg/kg) was antagonized by prior subcutaneous injection of bicuculline (1 mg/kg), but not by prior subc... |
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Increased c-Fos expression in select lateral parabrachial subnuclei following chemical versus electrical stimulation of the dorsal periaqueductal gray in rats.
Brain Res. 974(1-2) , 153-66, (2003) The parabrachial nucleus (PBN) is located in the rostral dorsolateral pons and has been identified as a critical relay for cardiovascular responses (sympathoexcitation and baroreflex attenuation) evoked by the dorsal periaqueductal gray (PAG). We examined the... |
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The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array.
Neuropharmacology 60(7-8) , 1142-53, (2011) Epileptiform discharges recorded in the 4-aminopyridine (4-AP) in vitro epilepsy model are mediated by glutamatergic and GABAergic signaling. Using a 60-channel perforated multi-electrode array (pMEA) on corticohippocampal slices from 2 to 3 week old mice we ... |
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Origin of synchronized oscillations induced by neocortical disinhibition in vivo.
J. Neurosci. 20(24) , 9195-206, (2000) During disinhibition, the neocortex generates synchronous activities. Block of GABA(A) receptors in neocortex transforms cortical slow-wave oscillations into large-amplitude approximately 1 Hz discharges consisting of a negative spike or multiple negative spi... |
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Pharmacological modulation of SK3 channels.
Neuropharmacology 40(7) , 879-87, (2001) Small-conductance, calcium-activated K+ channels (SK channels) are voltage-insensitive channels that have been identified molecularly within the last few years. As SK channels play a fundamental role in most excitable cells and participate in afterhyperpolari... |
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Electrophysiological studies of the GABAA receptor ligand, 4-PIOL, on cultured hippocampal neurones.
Br. J. Pharmacol. 104(1) , 85-90, (1991) 1. Whole-cell, patch-clamp recordings from cultured hippocampal neurones have been used to characterize the action of the GABAA ligand, 5-(4-piperidyl)isoxazol-3-ol (4-PIOL). The action of 4-PIOL was compared with that of the established GABAA agonist, isoguv... |
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GABA uptake via GABA transporter-1 modulates GABAergic transmission in the immature hippocampus.
J. Neurosci. 24(26) , 5877-80, (2004) GABA uptake limits GABA actions during synaptic responses when the density of active release sites is high or multiple axons are synchronously activated. GABA transporter-1 (GAT-1) is the main neuronal GABA transporter subtype and is already expressed in the ... |
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Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats
Neurobiol. Aging 33(9) , 1938-49, (2012) Alterations in the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPA-R) and N-methyl-D-aspartate receptor (NMDA-R) have been documented in aged animals and may contribute to changes in hippocampal-dependent memory. Growth hormone (GH) regula... |
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Non-cholinergic synaptic excitation in neostriatum: pharmacological evidence for mediation by a glutamate-like transmitter.
Br. J. Pharmacol. 88(4) , 847-56, (1986) We studied the synaptic pharmacology of an excitatory pathway in the neostriatum using electrophysiological techniques in tissue slices from rats. In response to single electrical stimuli, two negative, extracellular potentials (N-1 and N-2) were recorded thr... |