大麻隆
大麻隆结构式
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常用名 | 大麻隆 | 英文名 | (−)-nabilone |
|---|---|---|---|---|
| CAS号 | 51022-71-0 | 分子量 | 372.541 | |
| 密度 | 1.0±0.1 g/cm3 | 沸点 | 457.4±45.0 °C at 760 mmHg | |
| 分子式 | C24H36O3 | 熔点 | 155-156ºC | |
| MSDS | 美版 | 闪点 | 145.4±22.2 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Oral nabilone capsules in the treatment of chemotherapy-induced nausea and vomiting and pain.
Expert Opin. Investig. Drugs 17(1) , 85-95, (2008) Nabilone has been approved to treat chemotherapy-induced nausea and vomiting. Recent studies have explored cannabinoids in pain management.To review the evidence for the use of cannabinoids in general and nabilone in particular; i) in managing chemotherapy-in... |
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A randomized, double-blinded, crossover pilot study assessing the effect of nabilone on spasticity in persons with spinal cord injury.
Arch. Phys. Med. Rehabil. 91(5) , 703-7, (2010) To determine whether nabilone, a synthetic cannabinoid, alleviates spasticity in people with spinal cord injury (SCI).A double-blind, placebo-controlled crossover study.Outpatient rehabilitation clinics.We recruited volunteers (N=12) with SCI and spasticity. ... |
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An open-label comparison of nabilone and gabapentin as adjuvant therapy or monotherapy in the management of neuropathic pain in patients with peripheral neuropathy.
Pain Pract. 11(4) , 353-68, (2011) Neuropathic pain (NeP) is prevalent in patients with peripheral neuropathy (PN), regardless of etiology. We sought to compare the efficacy of the cannabinoid nabilone as either monotherapy or adjuvant therapy with a first-line medication for NeP, gabapentin, ... |
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Subjective, cognitive and cardiovascular dose-effect profile of nabilone and dronabinol in marijuana smokers.
Addict. Biol. 18(5) , 872-81, (2013) Marijuana dependence is a substantial public health problem, with existing treatments showing limited efficacy. In laboratory and clinical studies, the cannabinoid receptor 1 agonist oral Δ9tetrahydrocannabinol (THC; dronabinol) has been shown to decrease mar... |
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Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting.
J. Natl. Compr. Canc. Netw. 10(4) , 487-92, (2012) Before the introduction of the serotonin receptor antagonists (5-HT3 receptor antagonists) in the early 1990s, limited effective options were available to prevent and treat chemotherapy-induced nausea and vomiting (CINV). In 1985, the FDA approved 2 cannabino... |
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Analgesic and antihyperalgesic effects of nabilone on experimental heat pain.
Curr. Med. Res. Opin. 24(4) , 1017-24, (2008) In this study, we explored the analgesic and antihyperalgesic properties of a synthetic cannabinoid (nabilone) on experimental heat pain in men and women, as well as its effects on descending pain inhibitory systems.A double-blind, placebo controlled, crossov... |
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Cloning and pharmacological characterization of the dog cannabinoid CB₂receptor.
Eur. J. Pharmacol. 669(1-3) , 24-31, (2011) Comparison of human, rat and mouse cannabinoid CB(2) receptor primary sequences has shown significant divergence at the mRNA and protein sequence level, raising the possibility of species specific pharmacological properties. Additionally, given the importance... |
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Lack of effect of central nervous system-active doses of nabilone on capsaicin-induced pain and hyperalgesia.
Clin. Exp. Pharmacol. Physiol. 39(4) , 336-42, (2012) The aim of the present study was to investigate the effects of nabilone on capsaicin-induced pain and hyperalgesia, as well as on biomarkers of cannabinoid central nervous system (CNS) effects. A randomized, double-blind, placebo-controlled, crossover study w... |
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Nabilone for the treatment of medication overuse headache: results of a preliminary double-blind, active-controlled, randomized trial.
J. Headache Pain 13(8) , 677-84, (2012) Medication overuse headache (MOH) is a severe burden to sufferers and its treatment has few evidence-based indications. The aim of this study is to evaluate efficacy and safety of nabilone in reducing pain and frequency of headache, the number of analgesic in... |
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Nabilone produces marked impairments to cognitive function and changes in subjective state in healthy volunteers.
J. Psychopharmacol. 24(11) , 1659-69, (2010) This was a double-blind, randomised, placebo-controlled, crossover study of the acute cognitive and subjective effects of nabilone 1-3 mg in healthy male volunteers. The Cognitive Drug Research computerised system (CDR system) was used to assess changes in at... |