氯谷胺
氯谷胺结构式
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常用名 | 氯谷胺 | 英文名 | Loxiglumide |
|---|---|---|---|---|
| CAS号 | 107097-80-3 | 分子量 | 461.37900 | |
| 密度 | 1.233g/cm3 | 沸点 | 632.2ºC at 760mmHg | |
| 分子式 | C21H30Cl2N2O5 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 336.1ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Involvement of capsaicin-sensitive afferent nerves and cholecystokinin 2/gastrin receptors in gastroprotection and adaptation of gastric mucosa to Helicobacter pylori-lipopolysaccharide.
J. Pharmacol. Exp. Ther. 310(1) , 116-25, (2004) Lipopolysaccharide (LPS) is one of the virulence factors in the Helicobacter pylori (Hp)-infected stomach, but it remains unknown whether single and prolonged pretreatment with Hp-LPS can affect the course of gastric damage induced by aspirin (ASA). We compar... |
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Effect of cholecystokinin-A receptor blockade on postprandial insulinaemia and gastric emptying in humans.
Neurogastroenterol. Motil. 14(5) , 519-25, (2002) Our aim was determine the relationship between cholecystokinin (CCK)-A receptor blockade, glucose levels, insulin secretion and gastric emptying in humans, and to assess the effect of CCK-A blockade on pancreatic polypeptide secretion. After a 12-h fast, six ... |
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Stimulatory effect of N-methyltyramine, a congener of beer, on pancreatic secretion in conscious rats.
Alcohol. Clin. Exp. Res. 34 Suppl 1 , S14-7, (2010) Alcoholic beverages stimulate gastric acid secretion and increase the appetite. Although ingested ethanol stimulates pancreatic secretion, alcoholic beverages contain several congeners. N-methyltyramine (NMT) was isolated from beer as a factor in stimulating ... |
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Inhibitory effect of loxiglumide (CR 1505), a cholecystokinin receptor antagonist, on N-nitrosobis(2-oxopropyl) amine-induced biliary carcinogenesis in Syrian hamsters.
World J. Surg. 26(3) , 359-65, (2002) We evaluated the cholecystokinin (CCK) receptor antagonist loxiglumide (CR1505) for a possible inhibitory effect on biliary carcinogenesis in a hamster model. Experimental group I underwent cholecystoduodenostomy and ligation of the distal end of the common b... |
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Effects of the cholecystokinin A receptor antagonist loxiglumide on the proliferation and cell cycle time of pancreatic acinar cells in rats.
Pancreas 32(2) , 190-6, (2006) Prior studies have indicated that endogenous or exogenous cholecystokinin (CCK) induces transient acinar cell proliferation at about 24 hours after its stimulation. The aims of the present study were to determine the time point when the administration of the ... |
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Sensitive SPE-HPLC method to determine a novel angiotensin-AT1 antagonist in biological samples.
J. Pharm. Biomed. Anal. 35(2) , 321-9, (2004) A high-performance liquid chromatography (HPLC)-method after solid-phase extraction (SPE) has been developed in order to determine a new angiotensin-AT1 antagonist, i.e. CR 3210 (C27H24N8; MW = 460.54), 4-[4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)me... |
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Eradication of Helicobacter pylori restores the inhibitory effect of cholecystokinin on gastric motility in duodenal ulcer patients.
Scand. J. Gastroenterol. 36(3) , 241-6, (2001) Increased gastric emptying and defective action of endogenous cholecystokinin (CCK), that is known to inhibit this emptying, have been implicated in the pathogenesis of duodenal ulcer (DU). The aim of this double blind study was to assess whether CCK and soma... |
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The effects on diet, anastomotic type, and loxiglumide on gastric emptying following gastrojejunostomy.
Int. J. Surg. 7(2) , 163-7, (2009) The effects on gastric emptying of feeding with a normal diet (ND), an early high-calorie and hyperosmolar diet (HCHOD) or normal diet plus intraperitoneal loxiglumide (LOX) were investigated in rats with antecolic (ACGJ) or retrocolic (RCGJ) gastrojejunostom... |
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Effect of cholecystokinin1 receptor antagonist loxiglumide (CR1505) on basal pancreatic exocrine secretion in conscious rats.
Pancreas 26(1) , 87-91, (2003) To examine the involvement of cholecystokinin (CCK) in the basal pancreatic exocrine, we investigated the effect of loxiglumide (CR1505), a CCK1 receptor antagonist, on basal pancreatic exocrine secretion in conscious rats.After the basal collection of pancre... |
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The effects of an essential fatty acid compound and a cholecystokinin-8 antagonist on iron deficiency induced anorexia and learning deficits.
Nutr. Neurosci. 7(2) , 85-90, (2004) Iron deficiency (ID) is among the most common nutritional diseases, causing deleterious effects that include decreases in cognitive function and weight loss. The ID also induces a reduction in the number and affinity of dopaminergic D2 receptors. The new find... |