孕烷醇酮
孕烷醇酮结构式
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常用名 | 孕烷醇酮 | 英文名 | Pregnanolone |
|---|---|---|---|---|
| CAS号 | 128-20-1 | 分子量 | 318.493 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 431.2±18.0 °C at 760 mmHg | |
| 分子式 | C21H34O2 | 熔点 | 149ºC | |
| MSDS | 中文版 美版 | 闪点 | 183.9±13.8 °C | |
| 符号 |
GHS08 |
信号词 | Warning |
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A liquid chromatography-tandem mass spectrometry-based method for the simultaneous determination of hydroxy sterols and bile acids.
J. Chromatogr. A. 1371 , 184-95, (2014) Recently, hydroxy sterols and bile acids have gained growing interest as they are important regulators of energy homoeostasis and inflammation. The high number of different hydroxy sterols and bile acid species requires powerful analytical tools to quantify t... |
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Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research.
Mol. Pharmacol. 86(6) , 635-46, (2014) A critical obstacle to developing effective medications to prevent and/or treat alcohol use disorders is the lack of specific knowledge regarding the plethora of molecular targets and mechanisms underlying alcohol (ethanol) action in the brain. To identify th... |
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Quantification of ten neuroactive steroids in plasma in Withdrawal Seizure-Prone and -Resistant mice during chronic ethanol withdrawal.
Psychopharmacol. Ser. 231(17) , 3401-14, (2014) The rapid membrane actions of neuroactive steroids, particularly via an enhancement of γ-aminobutyric acidA receptors (GABAARs), participate in the regulation of central nervous system excitability. Prior evidence suggests an inverse relationship between endo... |
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Modulation of allopregnanolone on excitatory transmitters release from single glutamatergic terminal.
Brain Res. Bull. 93 , 39-46, (2013) Neurosteroids such as allopregnanolone (Allo) are widely distributed in the brain and may modulate neuronal excitability under physiological or pathological states. Allo modulates GABAA receptor responses, and in this study we investigated the functional effe... |
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Quantification of neurosteroids during pregnancy using selective ion monitoring mass spectrometry.
Steroids 95 , 24-31, (2015) Analytical techniques used to quantify neurosteroids in biological samples are often compromised by non-specificity and limited dynamic range which can result in erroneous results. A relatively rapid and inexpensive gas chromatography-mass spectrometry (GC-MS... |
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Effect of ursodeoxycholic acid treatment on the altered progesterone and bile acid homeostasis in the mother-placenta-foetus trio during cholestasis of pregnancy.
Br. J. Clin. Pharmacol. 79(2) , 316-29, (2015) Intrahepatic cholestasis of pregnancy (ICP) is characterized by pruritus and elevated bile acid concentrations in maternal serum. This is accompanied by an enhanced risk of intra-uterine and perinatal complications. High concentrations of sulphated progestero... |
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Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3α,5α-THP and reduces long-term operant ethanol self-administration.
J. Neurosci. 34(17) , 5824-34, (2014) Neuroactive steroids are endogenous neuromodulators capable of altering neuronal activity and behavior. In rodents, systemic administration of endogenous or synthetic neuroactive steroids reduces ethanol self-administration. We hypothesized this effect arises... |
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Allopregnanolone levels and seizure frequency in progesterone-treated women with epilepsy.
Neurology 83(4) , 345-8, (2014) To determine whether allopregnanolone (AP) may mediate seizure reduction in progesterone-treated women with epilepsy.The NIH Progesterone Trial compared the efficacy of adjunctive cyclic natural progesterone therapy vs placebo treatment of intractable seizure... |
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Estrous cycle regulation of extrasynaptic δ-containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis.
J. Pharmacol. Exp. Ther. 346(1) , 146-60, (2013) The ovarian cycle affects susceptibility to behavioral and neurologic conditions. The molecular mechanisms underlying these changes are poorly understood. Deficits in cyclical fluctuations in steroid hormones and receptor plasticity play a central role in phy... |
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Progesterone and allopregnanolone improves stroke outcome in male mice via distinct mechanisms but neither promotes neurogenesis.
J. Neurochem. 132(1) , 32-7, (2015) Based on the outcome of a number of experimental studies, progesterone (PROG) holds promise as a new therapy for stroke. To understand more about the mechanisms involved, we administered PROG (or the major metabolite, allopregnanolone, ALLO), intra-peritoneal... |