3-甲氧基-5-(三氟甲基)苯胺
3-甲氧基-5-(三氟甲基)苯胺结构式
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常用名 | 3-甲氧基-5-(三氟甲基)苯胺 | 英文名 | 3-Methoxy-5-(trifluoromethyl)aniline |
|---|---|---|---|---|
| CAS号 | 349-55-3 | 分子量 | 191.150 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 242.0±40.0 °C at 760 mmHg | |
| 分子式 | C8H8F3NO | 熔点 | 50-52 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 100.2±27.3 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK).
Bioorg. Med. Chem. Lett. 18(23) , 6231-5, (2008) A series of SYK inhibitors based on the phenylamino pyrimidine thiazole lead 4 were prepared and evaluated for biological activity. Lead optimization provided compounds with nanomolar K(i)'s against SYK and potent inhibition in mast cell degranulation assays. |
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