ASN-ASP-ASP-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BRIDGE: CYS4-CYS12,CYS7-CYS15)
ASN-ASP-ASP-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BRIDGE: CYS4-CYS12,CYS7-CYS15)结构式
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常用名 | ASN-ASP-ASP-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BRIDGE: CYS4-CYS12,CYS7-CYS15) | 英文名 | Uroguanylin Topoisomer A (human) trifluoroacetate salt |
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| CAS号 | 154525-25-4 | 分子量 | 1667.86000 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C64H102N18O26S4 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Characterization of immunological cross-reactivity between enterotoxigenic Escherichia coli heat-stable toxin and human guanylin and uroguanylin.
Infect. Immun. 82(7) , 2913-22, (2014) Enterotoxigenic Escherichia coli (ETEC) expressing the heat-stable toxin (ST) (human-type [STh] and porcine-type [STp] variants) is among the five most important enteric pathogens in young children living in low- and middle-income countries. ST mediates diarr... |
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A uroguanylin-GUCY2C endocrine axis regulates feeding in mice.
J. Clin. Invest. 121 , 3578-3588, (2011) Intestinal enteroendocrine cells are critical to central regulation of caloric consumption, since they activate hypothalamic circuits that decrease appetite and thereby restrict meal size by secreting hormones in response to nutrients in the gut. Although gua... |
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Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase.
Proc. Natl. Acad. Sci. U. S. A. 90 , 10464, (1993) The intestinal hormone guanylin and bacterial heat-stable enterotoxins (STs) are members of a peptide family that activates intestinal membrane guanylate cyclase. Two different peptides that activate the human intestinal T84 cell guanylate cyclase have been p... |
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Guanylin regulatory peptides: structures, biological activities mediated by cyclic GMP and pathobiology.
Regul. Pept. 81 , 25-39, (1999) The guanylin family of bioactive peptides consists of three endogenous peptides, including guanylin, uroguanylin and lymphoguanylin, and one exogenous peptide toxin produced by enteric bacteria. These small cysteine-rich peptides activate cell-surface recepto... |
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The rat kidney contains high levels of prouroguanylin (the uroguanylin precursor) but does not express GC-C (the enteric uroguanylin receptor).
Am. J. Physiol. Renal Physiol. 300 , F561-573, (2011) The peptide uroguanylin (Ugn) regulates enteric and renal electrolyte transport. Previous studies have shown that Ugn and its receptor GC-C (a ligand-activated guanylate cyclase) are abundant in the intestine. Less is known about Ugn and GC-C expression in th... |
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Uroguanylin: how the gut got another satiety hormone.
J. Clin. Invest. 121 , 3384-3386, (2011) Prouroguanylin is a gastrointestinal paracrine signal and prohormone that is secreted after nutrient ingestion. In this issue of the JCI, Valentino et al. show that prouroguanylin is converted to uroguanylin in the CNS, which can activate guanylyl cyclase 2C ... |
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Uroguanylin levels in intestine and plasma are regulated by nutritional status in a leptin-dependent manner.
Eur. J. Nutr. 55 , 529-36, (2016) Uroguanylin (UGN) is a 16 amino acid peptide produced mainly by intestinal epithelial cells. Nutrients intake increases circulating levels of prouroguanylin that is processed and converted to UGN to activate the guanylyl cyclase 2C receptor (GUCY2C). Given th... |