ASN-ASP-ASP-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BRIDGE: CYS4-CYS12,CYS7-CYS15)

更新时间:2024-01-02 21:21:40

ASN-ASP-ASP-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BRIDGE: CYS4-CYS12,CYS7-CYS15)结构式
ASN-ASP-ASP-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BRIDGE: CYS4-CYS12,CYS7-CYS15)结构式
品牌特惠专场
常用名 ASN-ASP-ASP-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BRIDGE: CYS4-CYS12,CYS7-CYS15) 英文名 Uroguanylin Topoisomer A (human) trifluoroacetate salt
CAS号 154525-25-4 分子量 1667.86000
密度 N/A 沸点 N/A
分子式 C64H102N18O26S4 熔点 N/A
MSDS 中文版 美版 闪点 N/A

 用途

tip
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Uroguanylin (human) 是在转移性结直肠癌肿瘤中表达的观音酰环化酶(GCC)受体的天然配体。Guanylyl Cyclase 在人结肠癌动物模型具有抗肿瘤作用。

 名称

中文名 ASN-ASP-ASP-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BRIDGE: CYS4-CYS12,CYS7-CYS15)
英文名 asn-asp-asp-cys-glu-leu-cys-val-asn-val-ala-cys-thr-gly-cys-leu
英文别名 更多

 生物活性

描述 Uroguanylin (human) 是在转移性结直肠癌肿瘤中表达的观音酰环化酶(GCC)受体的天然配体。Guanylyl Cyclase 在人结肠癌动物模型具有抗肿瘤作用。
相关类别
参考文献

[1]. Lewis DK, et al. Hypertrehalosemic hormone in a cockroach: molecular cloning and expression. Mol Cell Endocrinol. 1997;130(1-2):101-108.  

 物理化学性质

分子式 C64H102N18O26S4
分子量 1667.86000
精确质量 1666.61000
PSA 819.33000

 安全信息

个人防护装备 Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码 NONH for all modes of transport
WGK德国 3

 文献7

更多文献
Characterization of immunological cross-reactivity between enterotoxigenic Escherichia coli heat-stable toxin and human guanylin and uroguanylin.

Infect. Immun. 82(7) , 2913-22, (2014)

Enterotoxigenic Escherichia coli (ETEC) expressing the heat-stable toxin (ST) (human-type [STh] and porcine-type [STp] variants) is among the five most important enteric pathogens in young children li...

A uroguanylin-GUCY2C endocrine axis regulates feeding in mice.

J. Clin. Invest. 121 , 3578-3588, (2011)

Intestinal enteroendocrine cells are critical to central regulation of caloric consumption, since they activate hypothalamic circuits that decrease appetite and thereby restrict meal size by secreting...

Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase.

Proc. Natl. Acad. Sci. U. S. A. 90 , 10464, (1993)

The intestinal hormone guanylin and bacterial heat-stable enterotoxins (STs) are members of a peptide family that activates intestinal membrane guanylate cyclase. Two different peptides that activate ...

 英文别名

asn-asp-asp-cys-glu-leu-cys-val-asn-val-ala-cys-thr-gly-cys-leu [disulfide bridges: 4-12,7-15]
UGN (HUMAN)
Uroguanylin (huMan)UGN (huMan)
UROGUANYLIN
Uroguanylin
UROGUANYLIN (HUMAN)