Uroguanylin Topoisomer A (human) trifluoroacetate salt

Modify Date: 2025-08-24 00:00:34

Uroguanylin Topoisomer A (human) trifluoroacetate salt structure	Common Name	Uroguanylin Topoisomer A (human) trifluoroacetate salt
	CAS Number	154525-25-4	Molecular Weight	1667.86000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆₄H₁₀₂N₁₈O₂₆S₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of Uroguanylin Topoisomer A (human) trifluoroacetate salt

Uroguanylin (human) is a natural ligand for the Guanylyl Cyclase (GCC) receptor expressed in metastatic colorectal cancer tumors. Uroguanylin (human) has anti-tumor actions in an animal model for human colon cancer[1][2].

Name	asn-asp-asp-cys-glu-leu-cys-val-asn-val-ala-cys-thr-gly-cys-leu
Synonym	More Synonyms

Description	Uroguanylin (human) is a natural ligand for the Guanylyl Cyclase (GCC) receptor expressed in metastatic colorectal cancer tumors. Uroguanylin (human) has anti-tumor actions in an animal model for human colon cancer[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Guanylate Cyclase
References	[1]. Lewis DK, et al. Hypertrehalosemic hormone in a cockroach: molecular cloning and expression. Mol Cell Endocrinol. 1997;130(1-2):101-108.

Molecular Formula	C₆₄H₁₀₂N₁₈O₂₆S₄
Molecular Weight	1667.86000
Exact Mass	1666.61000
PSA	819.33000
InChIKey	VQZRYOAXGUCZMI-HWMZBCIHSA-N
SMILES	CC(C)CC(NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(N)CC(N)=O)CSSCC(NC(=O)C(C)NC(=O)C(C(C)C)NC(=O)C(CC(N)=O)NC(=O)C(C(C)C)NC2=O)C(=O)NC(C(C)O)C(=O)NCC(=O)N1)C(=O)O

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

Characterization of immunological cross-reactivity between enterotoxigenic Escherichia coli heat-stable toxin and human guanylin and uroguanylin.

Infect. Immun. 82(7) , 2913-22, (2014)

Enterotoxigenic Escherichia coli (ETEC) expressing the heat-stable toxin (ST) (human-type [STh] and porcine-type [STp] variants) is among the five most important enteric pathogens in young children li...

A uroguanylin-GUCY2C endocrine axis regulates feeding in mice.

J. Clin. Invest. 121 , 3578-3588, (2011)

Intestinal enteroendocrine cells are critical to central regulation of caloric consumption, since they activate hypothalamic circuits that decrease appetite and thereby restrict meal size by secreting...

Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase.

Proc. Natl. Acad. Sci. U. S. A. 90 , 10464, (1993)

The intestinal hormone guanylin and bacterial heat-stable enterotoxins (STs) are members of a peptide family that activates intestinal membrane guanylate cyclase. Two different peptides that activate ...

asn-asp-asp-cys-glu-leu-cys-val-asn-val-ala-cys-thr-gly-cys-leu [disulfide bridges: 4-12,7-15]

UGN (HUMAN)

Uroguanylin (huMan)UGN (huMan)

UROGUANYLIN

Uroguanylin

UROGUANYLIN (HUMAN)