Uroguanylin Topoisomer A (human) trifluoroacetate salt

Names

[ Name ]:
Uroguanylin Topoisomer A (human) trifluoroacetate salt

[Synonym ]:
asn-asp-asp-cys-glu-leu-cys-val-asn-val-ala-cys-thr-gly-cys-leu [disulfide bridges: 4-12,7-15]
UGN (HUMAN)
Uroguanylin (huMan)UGN (huMan)
UROGUANYLIN
Uroguanylin
UROGUANYLIN (HUMAN)

Biological Activity

[Description]:

Uroguanylin (human) is a natural ligand for the Guanylyl Cyclase (GCC) receptor expressed in metastatic colorectal cancer tumors. Uroguanylin (human) has anti-tumor actions in an animal model for human colon cancer[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Guanylate Cyclase

[References]

[1]. Lewis DK, et al. Hypertrehalosemic hormone in a cockroach: molecular cloning and expression. Mol Cell Endocrinol. 1997;130(1-2):101-108.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₄H₁₀₂N₁₈O₂₆S₄

[ Molecular Weight ]:
1667.86000

[ Exact Mass ]:
1666.61000

[ PSA ]:
819.33000

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Characterization of immunological cross-reactivity between enterotoxigenic Escherichia coli heat-stable toxin and human guanylin and uroguanylin.

Infect. Immun. 82(7) , 2913-22, (2014)

Enterotoxigenic Escherichia coli (ETEC) expressing the heat-stable toxin (ST) (human-type [STh] and porcine-type [STp] variants) is among the five most important enteric pathogens in young children li...

A uroguanylin-GUCY2C endocrine axis regulates feeding in mice.

J. Clin. Invest. 121 , 3578-3588, (2011)

Intestinal enteroendocrine cells are critical to central regulation of caloric consumption, since they activate hypothalamic circuits that decrease appetite and thereby restrict meal size by secreting...

Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase.

Proc. Natl. Acad. Sci. U. S. A. 90 , 10464, (1993)

The intestinal hormone guanylin and bacterial heat-stable enterotoxins (STs) are members of a peptide family that activates intestinal membrane guanylate cyclase. Two different peptides that activate ...

Related Compounds

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