CK-666
CK-666结构式
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常用名 | CK-666 | 英文名 | CK 666 |
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| CAS号 | 442633-00-3 | 分子量 | 296.33900 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C18H17FN2O | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Essential role of endocytosis for interleukin-4-receptor-mediated JAK/STAT signalling.
J. Cell Sci. 128 , 3781-95, (2015) Many important signalling cascades operate through specialized signalling endosomes, but a corresponding mechanism has as yet not been described for hematopoietic cytokine receptors. Based on live-cell affinity measurements, we recently proposed that ligand-i... |
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Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy.
Nat. Commun. 6 , 8045, (2015) Autophagy is an important degradation pathway, which is induced after starvation, where it buffers nutrient deprivation by recycling macromolecules in organisms from yeast to man. While the classical pathway mediating this response is via mTOR inhibition, the... |
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PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions.
J. Cell Biol. 210 , 753-69, (2015) Branched actin critically contributes to membrane trafficking by regulating membrane curvature, dynamics, fission, and transport. However, how actin dynamics are controlled at membranes is poorly understood. Here, we identify the branched actin regulator cort... |
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Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation.
Nat. Commun. 5 , 5511, (2014) Tissues use numerous mechanisms to change shape during development. The Drosophila egg chamber is an organ-like structure that elongates to form an elliptical egg. During elongation the follicular epithelial cells undergo a collective migration that causes th... |
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Actin nucleation by WH2 domains at the autophagosome.
Nat. Commun. 6 , 7888, (2015) Autophagy is a catabolic process whereby cytosolic components and organelles are degraded to recycle key cellular materials. It is a constitutive process required for proper tissue homoeostasis but can be rapidly regulated by a variety of stimuli (for example... |
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Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change.
Chem. Biol. 20(5) , 701-12, (2013) Actin-related protein 2/3 (Arp2/3) complex is a seven-subunit assembly that nucleates branched actin filaments. Small molecule inhibitors CK-666 and CK-869 bind to Arp2/3 complex and inhibit nucleation, but their modes of action are unknown. Here, we use bioc... |
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Actin recruitment to the Chlamydia inclusion is spatiotemporally regulated by a mechanism that requires host and bacterial factors.
PLoS ONE 7 , e46949, (2012) The ability to exit host cells at the end of their developmental growth is a critical step for the intracellular bacterium Chlamydia. One exit strategy, extrusion, is mediated by host signaling pathways involved with actin polymerization. Here, we show that a... |
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A dynamic formin-dependent deep F-actin network in axons.
J. Cell Biol. 210 , 401-17, (2015) Although actin at neuronal growth cones is well-studied, much less is known about actin organization and dynamics along axon shafts and presynaptic boutons. Using probes that selectively label filamentous-actin (F-actin), we found focal "actin hotspots" along... |
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Arp2/3 complex regulates asymmetric division and cytokinesis in mouse oocytes.
PLoS ONE 6 , e18392, (2011) Mammalian oocyte meiotic maturation involves oocyte polarization and a unique asymmetric division, but until now, the underlying mechanisms have been poorly understood. Arp2/3 complex has been shown to regulate actin nucleation and is widely involved in a div... |
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Novel identification of Dermacentor variabilis Arp2/3 complex and its role in rickettsial infection of the arthropod vector.
PLoS ONE 9(4) , e93768, (2014) Tick-borne spotted fever group (SFG) Rickettsia species must be able to infect both vertebrate and arthropod host cells. The host actin-related protein 2/3 (Arp2/3) complex is important in the invasion process and actin-based motility for several intracellula... |