CK 666

Modify Date: 2024-01-11 16:57:43

CK 666 Structure
CK 666 structure
Common Name CK 666
CAS Number 442633-00-3 Molecular Weight 296.33900
Density N/A Boiling Point N/A
Molecular Formula C18H17FN2O Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of CK 666


CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex, and binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation[1].

 Names

Name 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
Synonym More Synonyms

 CK 666 Biological Activity

Description CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex, and binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation[1].
Related Catalog
Target

Arp2/3 complex[1]

References

[1]. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12.

 Chemical & Physical Properties

Molecular Formula C18H17FN2O
Molecular Weight 296.33900
Exact Mass 296.13200
PSA 48.38000
LogP 4.16270

 Safety Information

RIDADR NONH for all modes of transport

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 Synonyms

2-fluoro-N-(2-(2-methyl-1H-indol-3-yl)ethyl)benzamide
CK-666