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6,7-二甲氧基-4-[N-(3-溴苯基)氨基]喹唑啉盐酸盐

6,7-二甲氧基-4-[N-(3-溴苯基)氨基]喹唑啉盐酸盐结构式
6,7-二甲氧基-4-[N-(3-溴苯基)氨基]喹唑啉盐酸盐结构式
品牌特惠专场
常用名 6,7-二甲氧基-4-[N-(3-溴苯基)氨基]喹唑啉盐酸盐 英文名 PD153035 HCl
CAS号 183322-45-4 分子量 396.666
密度 N/A 沸点 472.1ºC at 760 mmHg
分子式 C16H15BrClN3O2 熔点 265°C(lit.)
MSDS 中文版 美版 闪点 239.3ºC
符号 GHS05 GHS06
GHS05, GHS06
信号词 Danger

Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor.

PLoS Biol. 9 , e1001162, (2011)

In order to metastasize, cancer cells need to acquire a motile phenotype. Previously, development of this phenotype was thought to rely on the acquisition of selected, random mutations and thus would occur late in cancer progression. However, recent studies s...

Reduced annexin A6 expression promotes the degradation of activated epidermal growth factor receptor and sensitizes invasive breast cancer cells to EGFR-targeted tyrosine kinase inhibitors.

Mol. Cancer 12 , 167, (2014)

The expression of annexin A6 (AnxA6) in AnxA6-deficient non-invasive tumor cells has been shown to terminate epidermal growth factor receptor (EGFR) activation and downstream signaling. However, as a scaffolding protein, AnxA6 may stabilize activated cell-sur...

Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation.

Oncogene 30 , 3234-47, (2011)

Claudin-2 is a unique member of the claudin family of transmembrane proteins, as its expression is restricted to the leaky epithelium in vivo and correlates with epithelial leakiness in vitro. However, recent evidence suggests potential functions of claudin-2...