利马前列素
利马前列素结构式
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常用名 | 利马前列素 | 英文名 | Limaprost |
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| CAS号 | 74397-12-9 | 分子量 | 380.518 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 550.6±50.0 °C at 760 mmHg | |
| 分子式 | C22H36O5 | 熔点 | 97-100° | |
| MSDS | 中文版 美版 | 闪点 | 300.9±26.6 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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OP-1206, a prostaglandin E1 derivative, attenuates the thermal hyperesthesia induced by constriction injury to the sciatic nerve in the rat.
Anesth. Analg. 80(3) , 515-20, (1995) Nerve ischemia induces wallerian degeneration and peripheral neuropathy, the nerve constriction injury induces thermal hyperesthesia. Nerve ischemia is one possible mechanism in the development of thermal hyperesthesia in the nerve constriction injury model. ... |
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Inhibition of platelet aggregation by the cAMP-phosphodiesterase inhibitor, cilostamide, may not be associated with activation of cAMP-dependent protein kinase.
Cell. Signal. 4(4) , 453-63, (1992) We examined the involvement of cAMP-dependent protein kinase (A kinase)2 in the inhibition by cilostamide, a specific inhibitor of the low Km cAMP-phosphodiesterase (PDE), on 9,11-epithio-11,12-methanothromboxane A2 (STA2)-induced platelet aggregation. For co... |
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Correlation between methotrexate-induced intestinal damage and decrease in polyamine content.
Life Sci. 72(6) , 669-76, (2002) A synthetic analog of prostaglandin E(1), OP-1206 [17S, 20-dimethyl-trans-Delta(2)-prostaglandin E(1)] protects the small intestine from the methotrexate (MTX)-induced damage. The purpose of this study is to evaluate the protective effect of OP-1206 on the me... |
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A combination of the aldose reductase inhibitor, statil, and the prostaglandin E1 analogue, OP1206.alpha CD, completely improves sciatic motor nerve conduction velocity in streptozocin-induced chronically diabetic rats.
Metab. Clin. Exp. 41(7) , 778-82, (1992) In view of the possible implication of multifactorial mechanisms in the pathogenesis of diabetic neuropathy, the aldose reductase inhibitor (ARI), Statil, which ameliorates abnormal sorbitol or myo-inositol metabolism in diabetic nerves, and the prostaglandin... |
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Stimulation of intestinal epithelial restitution by prostaglandin E(1) analogue.
Cancer Chemother. Pharmacol. 51(3) , 216-20, (2003) 5-Fluorouracil (5-FU) causes intestinal mucosal damage and malabsorption. We have recently reported that coadministration of 17 S,20-dimethyl- trans- lower right triangle (2)-prostaglandin E(1) (OP-1206), a stable synthetic analogue of prostaglandin E(1), wit... |
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Effects of OP-1206 alpha-CD on walking dysfunction in the rat neuropathic intermittent claudication model: comparison with nifedipine, ticlopidine and cilostazol.
Prostaglandins Other Lipid Mediat. 71(3-4) , 253-63, (2003) The systemic treatment effects of OP-1206 alpha-CD (17S-20-dimethyl-trans-delta 2-PGE1 alpha-cyclodextrin clathrate), a prostaglandin E1 (PGE1) analogue, on walking dysfunction, spinal cord blood flow (SCBF) and skin blood flow (SKBF) were assessed in the rat... |
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Apoptosis and impaired axonal regeneration of sensory neurons after nerve crush in diabetic rats.
Neuroreport 11(4) , 663-7, (2000) We investigated the possible induction of apoptosis of dorsal root ganglion (DRG) neurons and the defect of nerve regeneration after crush injury with reference to the JNK/c-jun and cAMP pathway in streptozocin-induced diabetic rats. In addition, the effects ... |
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Effect of a synthetic analog of prostaglandin E1 on the intestinal mucosa of methotrexate-treated rats.
Anticancer Res. 21(3B) , 1913-7, (2001) Administration of methotrexate to rats sometimes induces small intestinal damage. A synthetic analog of prostaglandin E1, OP-1206 [17S,20-dimethyl-trans-delta2-prostaglandin E1] may possibly provide therapeutic benefits to help recovery from such small intest... |
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Effects of orally administered OP-1206 alpha-CD with loxoprofen-Na on walking dysfunction in the rat neuropathic intermittent claudication model.
Prostaglandins Leukot. Essent. Fatty Acids 69(4) , 269-73, (2003) An orally active prostaglandin E1 analogue, OP-1206 alpha-CD improves walking dysfunction in the rat spinal stenosis model. Loxoprofen-Na, a non-steroidal anti-inflammatory drug, is used to relieve chronic pain in patients with lumbar spinal canal stenosis. T... |
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Potent inhibition of superoxide anion generation by PGE1 and the PGE1 analogue OP-1206 in human PMN's--unrelated to its antiplatelet PGI2-like activity.
Vasa. Suppl. 17 , 11-6, (1987)
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