鼠尾草酚
鼠尾草酚结构式
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常用名 | 鼠尾草酚 | 英文名 | Carnosol |
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| CAS号 | 5957-80-2 | 分子量 | 330.418 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 524.8±50.0 °C at 760 mmHg | |
| 分子式 | C20H26O4 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 187.0±23.6 °C |
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Calcium and α-tocopherol suppress cured-meat promotion of chemically induced colon carcinogenesis in rats and reduce associated biomarkers in human volunteers.
Am. J. Clin. Nutr. 98(5) , 1255-62, (2013) Processed meat intake has been associated with increased colorectal cancer risk. We have shown that cured meat promotes carcinogen-induced preneoplastic lesions and increases specific biomarkers in the colon of rats.We investigated whether cured meat modulate... |
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Degradation study of carnosic acid, carnosol, rosmarinic acid, and rosemary extract (Rosmarinus officinalis L.) assessed using HPLC.
J. Agric. Food Chem. 60(36) , 9305-14, (2012) Rosemary, whose major caffeoyl-derived and diterpenoid ingredients are rosmarinic acid, carnosol, and carnosic acid, is an important source of natural antioxidants and is being recognized increasingly as a useful preservative, protectant, and even as a potent... |
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Relevance of carnosic acid, carnosol, and rosmarinic acid concentrations in the in vitro antioxidant and antimicrobial activities of Rosmarinus officinalis (L.) methanolic extracts.
J. Agric. Food Chem. 60(38) , 9603-8, (2012) The importance of the diterpenic and rosmarinic acid content in the biological activities of rosemary extracts has been studied previously, but how the relationship between the concentration of these components affects their antioxidant and antibacterial acti... |
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Carnosol, a constituent of Zyflamend, inhibits aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and mutagenesis.
Cancer Prev. Res. (Phila.) 5(4) , 593-602, (2012) The aryl hydrocarbon receptor (AhR), a ligand-activated member of the basic helix-loop-helix family of transcription factors, plays a significant role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. In the upper aerodigestive tract of humans,... |
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Upregulation of NF-E2-related factor-2-dependent glutathione by carnosol provokes a cytoprotective response and enhances cell survival.
Acta Pharmacol. Sin. 32(1) , 62-9, (2011) To explore whether glutathione (GSH) increased through Nrf-2 activation is involved in the cytoprotective effects of carnosol in HepG2 cells.Human hepatoma cell line HepG2 were exposed to rosemarry essential oil or carnosol. Cell viability was measured using ... |
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Carnosic acid induces the NAD(P)H: quinone oxidoreductase 1 expression in rat clone 9 cells through the p38/nuclear factor erythroid-2 related factor 2 pathway.
J. Nutr. 141(12) , 2119-25, (2011) The anticarcinogenic effect of rosemary has been partly attributed to the modulation of the activity and expression of phase II detoxification enzymes. Here we compared the effects of phenolic diterpenes from rosemary on the expression of NAD(P)H: quinone oxi... |
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Antiangiogenic effect of carnosic acid and carnosol, neuroprotective compounds in rosemary leaves.
Biosci. Biotechnol. Biochem. 76(1) , 115-9, (2012) Carnosic acid, a diterpene in rosemary, is considered to be beneficial in the prevention of chronic neurodegenerative diseases. Recently, it has been found that drugs with antiangiogenic activity lower the risk of neurodegenerative diseases. Thus it is of int... |
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The plant phenolic diterpene carnosol suppresses sodium nitroprusside-induced toxicity in c6 glial cells.
J. Agric. Food Chem. 58(3) , 1543-50, (2010) Carnosol, a naturally occurring bioactive phenolic diterpene originating from rosemary and sage, has been shown to exert antioxidant and anti-inflammatory effects. This study examined possible protective effects of carnosol on sodium nitroprusside (SNP)-induc... |
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Syntheses of carnosic acid and carnosol, anti-oxidants in Rosemary, from pisiferic acid, the major constituent of Sawara.
Chem. Pharm. Bull. 58(1) , 27-9, (2010) Carnosic acid (2), a major anti-oxidant in rosemary (Rosmarinus officinalis), was synthesized from pisiferic acid (1), the major constituent of Sawara (Chamaecyparis pisifera), via ortho-oxidation of the phenol using meta-chlorobenzoyl peroxide (mCBPO), chlor... |
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ent-Rosane and abietane diterpenoids as cancer chemopreventive agents.
Phytochemistry 72(4-5) , 385-90, (2011) Two ent-rosane- (cuzcol, 1 and 6-dehydroxycuzcol, 2) and a abietatriene- (salvadoriol, 3) type diterpenoids have been isolated from Maytenus cuzcoina and Crossopetalum uragoga, respectively, along with five known diterpene compounds (4-8). Their stereostructu... |