ILMOFOSINE
ILMOFOSINE结构式
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常用名 | ILMOFOSINE | 英文名 | ILMOFOSINE |
|---|---|---|---|---|
| CAS号 | 83519-04-4 | 分子量 | 525.76500 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C26H56NO5PS | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS06 |
信号词 | Danger |
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Phase I trial of ilmofosine as a 24 hour infusion weekly.
Invest. New Drugs 13(3) , 205-10, (1995) Ilmofosine, an ether lipid derivative of lysophosphatidylcholine has antineoplastic activity in vitro and in vivo. Maximum efficacy in preclinical models is associated with prolonged exposure to the drug. In a Phase I trial of a weekly 2 hour infusion schedul... |
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A phase II trial of ilmofosine in non-small cell bronchogenic carcinoma.
Invest. New Drugs 14(2) , 219-22, (1996) We have conducted a study of ilmofosine (1-hexadecylthio; 2-methoxyethyl-rac-glycero-3-phosphocholine) in non-small cell bronchogenic carcinoma, using a schedule of continuous infusion for 5 days and a dose of 300 mg/m2/day. Toxicities were gastrointestinal (... |
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Structure-function relationships of alkyl-lysophospholipid analogs in selective antitumor activity.
Lipids 28(6) , 511-6, (1993) This investigation was initiated in order to delineate the structure-function relationship of the anticancer alkyl-lysophospholipids and assess their degree of selective cytotoxicity toward neoplastic cells. A series of glycerol phosphocholine analogs with va... |
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Quaternary ammonium analogs of ether lipids inhibit the activation of protein kinase C and the growth of human leukemia cell lines.
Cancer Chemother. Pharmacol. 42(4) , 319-26, (1998) ET-18-OCH3 (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) is a representative of the first generation of antitumor ether lipids and is a model in the development of new compounds including a series of quaternary ammonium analogs (QAA). In the present... |
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Expression of two 50 kDa proteins is associated with sensitivity towards etherlipid analogues in the human leukaemia cell line HL 60.
Eur. J. Cancer 33(11) , 1875-80, (1997) Hexadecylphosphocholine (HePC) is a new etherphospholipid derived substance with pronounced antineoplastic activity. So far the mode of action of this compound has not been resolved. Therefore, we decided to approach this problem by generating HePC resistant ... |
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Cytotoxicity of ether phospholipid BM 41.440 on neuroblastoma cells.
J. Cancer Res. Clin. Oncol. 121(5) , 262-6, (1995) The thioether lysophospholipid BM 41.440 proved to be toxic against cells of two neuroblastoma cell lines in a dose- and time-dependent manner. The ID50 estimated in three different in vitro test systems declined from about 10 micrograms/ml after 24 h to 1 mi... |
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Aspects of the cytological activity of edelfosine, miltefosine, and ilmofosine in Leishmania donovani.
J. Parasitol. 92(5) , 877-83, (2006) To discover the mode of action of alkyl-lysophospholipids in Leishmania donovani, we studied the effects of edelfosine, miltefosine, and ilmofosine on intracellular pH, the parasite's cell cycle, and the induction of apoptosis. The effect of the alkyl-lysopho... |
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Effect of cell density on cytotoxicity of ether lipid analogues in variants of B16 murine melanoma.
Lipids 28(5) , 403-6, (1993) Ether lipids are defined here as analogues of naturally occurring lysophosphatidylcholines with cytotoxic activity against neoplastic cells. The activity of 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET18OMe) and 3-hexadecylmercapto-2-methoxymethy... |
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Effect of alkyl-lysophospholipids on some aspects of the metabolism of Leishmania donovani.
J. Parasitol. 93(5) , 1202-7, (2007) Alkyl-lysophospholipids (ALPs), developed initially to be antitumor agents, have proved highly effective in the treatment of visceral leishmaniasis, a disease caused by the species making up the protozoan complex Leishmania donovani. Although their effectiven... |
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Study of the stress proteins secreted by Leishmania donovani after treatment with edelfosine, mitelfosine and ilmofosine, and morphological alterations analyzed by electronic microscopy.
Parasite 16(3) , 215-21, (2009) We studied the stress proteins induced in protozoa Leishmania donovani after treatment with edelfosine, miltefosine and ilmofosine. We studied the morphological and structural modifications caused in the promastigote forms of the parasite after treatment with... |