氧化苦参碱； 苦参素
氧化苦参碱； 苦参素结构式
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常用名 | 氧化苦参碱； 苦参素 | 英文名 | oxymatrine |
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| CAS号 | 16837-52-8 | 分子量 | 264.363 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C15H24N2O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
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Oxymatrine targets EGFR(p-Tyr845) and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells.
Cancer Chemother. Pharmacol. 75(2) , 353-63, (2015) Oxymatrine (matrine oxide, matrine N-oxide, matrine 1-oxide) is one of the quinolizidine alkaloid compounds extracted from the root of Sophora flavescens (a traditional Chinese herb). Oxymatrine has been known for its chemoresistance and cytotoxic effects on ... |
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Screening for the efficacy on lipid accumulation in 3T3-L1 cells is an effective tool for the identification of new anti-diabetic compounds.
Biochem. Pharmacol. 84(6) , 830-7, (2012) Reducing lipid accumulation in insulin target tissues is critical for the treatment of type 2 diabetes. This study aimed to develop a biochemical assay in cells for high throughput (HTP) screening of anti-diabetic drugs by reducing lipid accumulation via diff... |
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Effects of oxymatrine on the neuropathic pain induced by chronic constriction injury in mice.
CNS Neurosci. Ther. 18(12) , 1030-2, (2012)
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[Simultaneous determination of 7 alkaloid in herba Sophorae Alopecuroidis by HPLC].
Zhongguo Zhong Yao Za Zhi 36(11) , 1483-6, (2011) To establish a method for determination of 7 alkaloid in Herba Sophorae Alopecuroidis by HPLC.X-Brige C18 (4.6 mm x 200 mm, 5 microm) column was used with acetonitriles-0.05 mol x L(-1) KH2PO4 solution (2.0 mL x L(-1) triethylamine) with gradient elution as t... |
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Oxymatrine induces apoptosis in human cervical cancer cells through guanine nucleotide depletion.
Anticancer Drugs 25(2) , 161-73, (2014) Oxymatrine is an alkaloid obtained primarily from Sophora roots and has been shown to show anticancer effects in various cancers. However, the cellular and molecular effects of this agent on cervical cancer have been poorly characterized. Here, we investigate... |
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Effect of oxymatrine, the active component from Radix Sophorae flavescentis (Kushen), on ventricular remodeling in spontaneously hypertensive rats.
Phytomedicine 20(3-4) , 202-12, (2013) To examine the effects of oxymatrine (OMT) on ventricular remodeling in spontaneous hypertension rat (SHR) and the underlying mechanism.SHRs were divided into four groups: SHR control, SHR+40 mg/kg captopril, SHR+30 mg/kg OMT and SHR+60 mg/kg OMT. Normotensiv... |
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Determination of oxymatrine and its active metabolite matrine in human plasma after administration of oxymatrine oral solution by high-performance liquid chromatography coupled with mass spectrometry.
Fitoterapia 89 , 271-7, (2013) A rapid, sensitive and selective high-performance liquid chromatography mass spectrometric method has been developed and validated for the simultaneous determination of oxymatrine and its active metabolite matrine in human plasma after administration of oxyma... |
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Effect of oxymatrine on hepatic gene expression profile in experimental liver fibrosis of rats.
Chin. J. Integr. Med. 18(6) , 445-50, (2012) To investigate the effects of oxymatrine on hepatic gene expression profile in a rat model of liver fibrosis.Forty healthy male SD rats were randomly divided into three groups, a normal group (n=8), a model group (n=16), and an oxymatrine treatment group (n=1... |
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Effects of oxymatrine from Ku Shen on cancer cells.
Anticancer Agents Med. Chem. 9(8) , 823-6, (2009) Oxymatrine is one of active constituents isolated from Ku Shen, which is the dried root of Sophora flavescens Ait. The herb used in different herbal formulations is commonly known with specific pharmacological properties for treatment of liver disorders and o... |
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The effects of the combination of sodium ferulate and oxymatrine on lipopolysaccharide-induced acute lung injury in mice.
Inflammation 35(3) , 1161-8, (2012) In our previous study, the remarkable analgesic and anti-inflammatory effects of the combination of sodium ferulate (SF) and oxymatrine (OMT) had been found. In this study, we investigated the effect of the combination of SF and OMT on acute lung injury using... |