1,3-二氢-3-[(3,5-二甲基-1H-吡咯-2-基)亚甲基]-2H-吲哚-2-酮
![1,3-二氢-3-[(3,5-二甲基-1H-吡咯-2-基)亚甲基]-2H-吲哚-2-酮结构式](https://image.chemsrc.com/caspic/368/204005-46-9.png)
1,3-二氢-3-[(3,5-二甲基-1H-吡咯-2-基)亚甲基]-2H-吲哚-2-酮结构式
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常用名 | 1,3-二氢-3-[(3,5-二甲基-1H-吡咯-2-基)亚甲基]-2H-吲哚-2-酮 | 英文名 | SU5416 |
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| CAS号 | 204005-46-9 | 分子量 | 238.285 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 481.4±45.0 °C at 760 mmHg | |
| 分子式 | C15H14N2O | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 244.9±28.7 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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A novel murine model of severe pulmonary arterial hypertension.
Am. J. Respir. Crit. Care Med. 184(10) , 1171-82, (2011) The complex pathologies associated with severe pulmonary arterial hypertension (PAH) in humans have been a challenge to reproduce in mice due to the subtle phenotype displayed to PAH stimuli.Here we aim to develop a novel murine model of PAH that recapitulate... |
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Neurovascular development in the embryonic zebrafish hindbrain.
Dev. Biol. 357(1) , 134-51, (2011) The brain is made of billions of highly metabolically active neurons whose activities provide the seat for cognitive, affective, sensory and motor functions. The cerebral vasculature meets the brain's unusually high demand for oxygen and glucose by providing ... |
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SU5416, a VEGF receptor inhibitor and ligand of the AHR, represents a new alternative for immunomodulation.
PLoS ONE 7(9) , e44547, (2012) The experimental compound SU5416 went as far as Phase III clinical trials as an anticancer agent, putatively because of its activity as a VEGFR-2 inhibitor, but showed poor results. Here, we show that SU5416 is also an aryl hydrocarbon receptor (AHR) agonist ... |
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Unexpected neuronal protection of SU5416 against 1-Methyl-4-phenylpyridinium ion-induced toxicity via inhibiting neuronal nitric oxide synthase.
PLoS ONE 7(9) , e46253, (2012) SU5416 was originally designed as a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) for cancer therapy. In this study, we have found for the first time that SU5416 unexpectedly prevented 1-methyl-4-phenylpyridinium io... |