盐酸脱氧麻黄碱
一般危化品
盐酸脱氧麻黄碱结构式
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常用名 | 盐酸脱氧麻黄碱 | 英文名 | (+)-Metamfetamine hydrochloride |
|---|---|---|---|---|
| CAS号 | 51-57-0 | 分子量 | 185.694 | |
| 密度 | N/A | 沸点 | 215.5ºC at 760mmHg | |
| 分子式 | C10H16ClN | 熔点 | 166-168ºC | |
| MSDS | 中文版 美版 | 闪点 | 86.8ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
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Role of adenosine receptor subtypes in methamphetamine reward and reinforcement.
Neuropharmacology 89 , 265-73, (2014) The neurobiology of methamphetamine (MA) remains largely unknown despite its high abuse liability. The present series of studies explored the role of adenosine receptors on MA reward and reinforcement and identified alterations in the expression of adenosine ... |
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Ibudilast reverses the decrease in the synaptic signaling protein phosphatidylethanolamine-binding protein 1 (PEBP1) produced by chronic methamphetamine intake in rats.
Drug Alcohol Depend. 152 , 15-23, (2015) Chronic methamphetamine intake has been shown to induce a neuroinflammatory state leading to significant changes in brain functioning including behavioral changes. These changes can persist for years after drug use is discontinued and likely contribute to the... |
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Orexinergic neurotransmission in temperature responses to methamphetamine and stress: mathematical modeling as a data assimilation approach.
PLoS ONE 10 , e0126719, (2015) Orexinergic neurotransmission is involved in mediating temperature responses to methamphetamine (Meth). In experiments in rats, SB-334867 (SB), an antagonist of orexin receptors (OX1R), at a dose of 10 mg/kg decreases late temperature responses (t > 60 min) t... |
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Differential effects of NMDA receptor antagonists at lower and higher doses on basal gamma band oscillation power in rat cortical electroencephalograms.
Neuropharmacology 85 , 384-96, (2014) Schizophrenic patients have been shown to exhibit abnormal cortical gamma band oscillation (GBO), which is thought to be related to the symptoms of schizophrenia, including cognitive impairment. Recently, non-competitive NMDA receptor (NMDAr) antagonists such... |
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Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice.
Neuropharmacology 87 , 188-97, (2014) Chronic use of methamphetamine (METH) leads to long-lasting cognitive dysfunction in humans and in animal models. Modafinil is a wake-promoting compound approved for the treatment of sleeping disorders. It is also prescribed off label to treat METH dependence... |
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Withdrawal from long-term methamphetamine self-administration 'normalizes' neurometabolites in rhesus monkeys: a (1) H MR spectroscopy study.
Addict. Biol. 20(1) , 69-79, (2014) (1) H magnetic resonance spectroscopy has demonstrated alterations in several neurometabolites in methamphetamine (METH)-dependent individuals in brain regions implicated in addiction. Yet, it is unclear whether these neurochemicals return to homeostatic leve... |
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Discriminative-stimulus effects of second generation synthetic cathinones in methamphetamine-trained rats.
Drug Alcohol Depend. 149 , 280-4, (2015) Synthetic cathinones are beta-ketophenethylamine analogs manufactured to avoid legal restrictions placed on illicit stimulants like methamphetamine. Regulating these "emerging" designer drugs require scientific evidence of abuse potential.The present study ev... |
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Nicotine exposure beginning in adolescence enhances the acquisition of methamphetamine self-administration, but not methamphetamine-primed reinstatement in male rats.
Drug Alcohol Depend. 142 , 341-4, (2014) Nicotine is commonly abused in adolescence and is believed to be a "gateway" to other drugs of abuse [e.g., methamphetamine (METH)]. The relationship between early nicotine exposure and later METH use is complicated because the majority of juvenile smokers co... |
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Neurophysiologic and antipsychotic profiles of TASP0433864, a novel positive allosteric modulator of metabotropic glutamate 2 receptor.
J. Pharmacol. Exp. Ther. 351(3) , 642-53, (2014) Excess glutamatergic neurotransmission has been implicated in the pathophysiology of schizophrenia, and the activation of metabotropic glutamate 2 (mGlu2) receptor may exert antipsychotic effects by normalizing glutamate transmission. In the present study, we... |
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Methamphetamine drinking microstructure in mice bred to drink high or low amounts of methamphetamine.
Behav. Brain Res. 272 , 111-20, (2014) Genetic factors likely influence individual sensitivity to positive and negative effects of methamphetamine (MA) and risk for MA dependence. Genetic influence on MA consumption has been confirmed by selectively breeding mouse lines to consume high (MAHDR) or ... |