51-57-0

51-57-0结构式

常用中文名：盐酸脱氧麻黄碱
常用英文名：(+)-Metamfetamine hydrochloride
CAS号：51-57-0
分子式：C₁₀H₁₆ClN
分子量：185.694
相关类别：有机原料有机氟化合物氟苯硼酸系列
发布时间：2018-02-12 08:00:00
更新时间：2024-01-02 13:46:06

中文名	盐酸脱氧麻黄碱
英文名	methamphetamine hydrochloride
中文别名	去氧麻黄碱盐酸盐
英文别名	d-desoxyephedrine hydrochloride adipex d-Methylamphetamine hydrochloride (+)-N,α-dimethylphenethylamine hydrochloride (+)-Methamphetamine chloride Benzeneethanamine, N,α-dimethyl-, (αS)-, hydrochloride (1:1) d-N-Methyl-b-phenylisopropylamine Hydrochloride (+)METHAMPHETAMINE HYDROCHLORIDE Phenethylamine, N,α-dimethyl-, hydrochloride, (S)-(+)- doxyfed Hiropon DOE Methylisomyn Semoxydrine Madrine (aS)-N,a-Dimethylbenzeneethanamine Hydrochloride Destim METH TONEDRON (S)-(+)-N,a-Dimethylphenethylamine Hydrochloride D-N,α-Dimethylphenethylamine hydrochloride metamphetamine*HCl Isophen Benzeneethanamine, N,α-dimethyl-, hydrochloride, (S)- (9CI) S-(+)-Methamphetamine hydrochloride (+)-N-Methylamphetamine hydrochloride Doxephrin (2S)-N-Methyl-1-phenylpropan-2-amine hydrochloride (1:1) D-N-Methyl-β-phenylisopropylamine hydrochloride (S)-(+)-methamphetamine hydrochloride Desoxyn methedrine benzeneethanamine, N,α-dimethyl-, (αS)-, hydrochloride Desoxo 5 (2S)-N-methyl-1-phenylpropan-2-amine hydrochloride Syndrox Metamphetamine hydrochloride Pervitin (2S)-N-méthyl-1-phénylpropan-2-amine chlorhydrate (+)-N,a-Dimethylphenethylamine Hydrochloride Metamfetamine hydrochloride Benzeneethanamine, N,α-dimethyl-, hydrochloride, (S)- (+)-(S)-methylamphetamine hydrochloride dextim (+)-Methylamphetamine hydrochloride (S)-N,a-Dimethylbenzeneethanamine Hydrochloride deofed gerovit Desfedrin d-N,a-Dimethylphenethylamine Hydrochloride (+)-METHAMPHETAMINE HYDROCHLORIDE Methamphetamine hydrochloride Desoxyfed d-Methamphetamine hydrochloride (2S)-N-Methyl-1-phenylpropan-2-aminhydrochlorid (2S)-N-Methyl-1-phenyl-2-propanamine hydrochloride (1:1) dexoval

沸点	215.5ºC at 760mmHg
熔点	166-168ºC
分子式	C₁₀H₁₆ClN
分子量	185.694
闪点	86.8ºC
精确质量	185.097122
PSA	12.03000
LogP	3.02990
储存条件	库房低温,通风,干燥,与食品原料分开存放

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SH5455000

CHEMICAL NAME :: Phenethylamine, N,alpha-dimethyl-, hydrochloride, (S)-(+)-

CAS REGISTRY NUMBER :: 51-57-0

LAST UPDATED :: 199706

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C10-H15-N.Cl-H

MOLECULAR WEIGHT :: 185.72

WISWESSER LINE NOTATION :: 1MY1R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10930 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 253,466,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,346,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7560 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 87,214,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02170

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 84,351,1954 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg female 1-21 day(s) after conception lactating female 19 day(s) post-birth

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis

REFERENCE :: EAGRDS Experimental Aging Research. (Beech Hill Pub. Co., POB 136, Southwest Harbor, ME 04679) V.1- 1975- Volume(issue)/page/year: 5,509,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 792 mg/kg

SEX/DURATION :: male 4 week(s) pre-mating female 4 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: JONRA9 Journal of Neurochemistry. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) V.1- 1956- Volume(issue)/page/year: 20,625,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 80 mg/kg

SEX/DURATION :: female 13-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Specific Developmental Abnormalities - endocrine system Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: SYNAET Synapse. (Wiley-Liss, Inc., 605 Third Ave., New York, NY USA 10158-0012) V.1- 1987- Volume(issue)/page/year: 15,198,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 17 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: NHOZAX Nippon Hoigaku Zasshi. Japanese Journal of Legal Medicine. (Nippon Hoi Gakkai, c/o Tokyo Daigaku Igakubu Hoigaku Kyoshitsu, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1944- Volume(issue)/page/year: 46,126,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 19 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: NHOZAX Nippon Hoigaku Zasshi. Japanese Journal of Legal Medicine. (Nippon Hoi Gakkai, c/o Tokyo Daigaku Igakubu Hoigaku Kyoshitsu, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1944- Volume(issue)/page/year: 46,126,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6179 No. of Facilities: 28 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1579 (estimated) No. of Female Employees: 1099 (estimated)

符号	GHS06
信号词	Danger
危害声明	H301
警示性声明	P301 + P310
个人防护装备	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
风险声明 (欧洲)	25
危险品运输编码	UN 3249
RTECS号	SH5455000
包装等级	III
危险类别	6.1(b)
海关编码	2921499090

345-78-8

~80%

51-57-0

文献：David, Gabrielle E.; Hibbert, D. Brynn; Frew, Russell D.; Hayman, Alan R. Australian Journal of Chemistry, 2010 , vol. 63, # 1 p. 22 - 29

299-42-3

~50%

51-57-0

文献：Matsumoto, Teruki; Urano, Yasuteru; Makino, Yukiko; Kikura-Hanajiri, Ruri; Kawahara, Nobuo; Goda, Yukihiro; Nagano, Tetsuo Analytical Chemistry, 2008 , vol. 80, # 4 p. 1176 - 1181

50-98-6

~63%

51-57-0

文献：Matsumoto, Teruki; Urano, Yasuteru; Makino, Yukiko; Kikura-Hanajiri, Ruri; Kawahara, Nobuo; Goda, Yukihiro; Nagano, Tetsuo Analytical Chemistry, 2008 , vol. 80, # 4 p. 1176 - 1181

537-46-2

100-44-7

~0%

156-08-1

5411-22-3

详细

文献：MALLINCKRODT INC. Patent: WO2006/73547 A1, 2006 ; Location in patent: Page/Page column 7-8 ;

537-46-2

100-44-7

~99%

156-08-1

51-57-0

文献：MALLINCKRODT INC. Patent: WO2006/73547 A1, 2006 ; Location in patent: Page/Page column 6-7 ;

152614-95-4

51-57-0

文献：Pramanik, Chinmoy; Bapat, Kiran; Chaudhari, Ashok; Kulkarni, Mukund G.; Kolla, Rangarao; Sompalli, Srinivasarao; Tripathy, Narendra K.; Gurjar, Mukund K. Organic Process Research and Development, 2014 , vol. 18, # 4 p. 495 - 500

上游产品 5
345-78-8 299-42-3 50-98-6 537-46-2
100-44-7
下游产品 2
6192-97-8 5411-22-3

海关编码	2921499090
中文概述	2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

51-57-0	22930-85-4
350820-08-5	350820-07-4
50-98-6	134-71-4
136765-40-7	60124-88-1
33817-09-3	285979-73-9