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9H-茚并[1,2-b][1,2,5]恶二唑并[3,4-e]吡嗪-9-酮

9H-茚并[1,2-b][1,2,5]恶二唑并[3,4-e]吡嗪-9-酮结构式
9H-茚并[1,2-b][1,2,5]恶二唑并[3,4-e]吡嗪-9-酮结构式
品牌特惠专场
常用名 9H-茚并[1,2-b][1,2,5]恶二唑并[3,4-e]吡嗪-9-酮 英文名 Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one
CAS号 67200-34-4 分子量 224.175
密度 1.7±0.1 g/cm3 沸点 437.2±55.0 °C at 760 mmHg
分子式 C11H4N4O2 熔点 296 °C(dec.)
MSDS 中文版 美版 闪点 218.2±31.5 °C
符号 GHS07
GHS07
信号词 Warning

Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase.

Nat. Biotechnol. 28 , 738 - 742, (2010)

The target of rapamycin (TOR) plays a central role in eukaryotic cell growth control. With prevalent hyperactivation of the mammalian TOR (mTOR) pathway in human cancers, strategies to enhance TOR pathway inhibition are needed. We used a yeast-based screen to...