Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one

Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one Structure
Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one structure
Common Name Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one
CAS Number 67200-34-4 Molecular Weight 224.175
Density 1.7±0.1 g/cm3 Boiling Point 437.2±55.0 °C at 760 mmHg
Molecular Formula C11H4N4O2 Melting Point 296 °C(dec.)
MSDS Chinese USA Flash Point 218.2±31.5 °C
Symbol GHS07
GHS07
Signal Word Warning

Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase.

Nat. Biotechnol. 28 , 738 - 742, (2010)

The target of rapamycin (TOR) plays a central role in eukaryotic cell growth control. With prevalent hyperactivation of the mammalian TOR (mTOR) pathway in human cancers, strategies to enhance TOR pathway inhibition are needed. We used a yeast-based screen to...