8-O-乙酰哈巴苷
8-O-乙酰哈巴苷结构式
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常用名 | 8-O-乙酰哈巴苷 | 英文名 | 8-O-Acetylharpagide |
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| CAS号 | 6926-14-3 | 分子量 | 406.382 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | 607.2±55.0 °C at 760 mmHg | |
| 分子式 | C17H26O11 | 熔点 | 227-229℃ | |
| MSDS | 美版 | 闪点 | 215.9±25.0 °C |
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[Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens extract in beagle dog].
Zhongguo Zhong Yao Za Zhi 38(12) , 2015-8, (2013) 8-O-acetylharpagide and harpagide are two kinds of effective component of Ajuga decumbens extract. A sensitive LC-MS/MS method has been established for pharmacokinetics of 8-O-acetylharpagide and harpagide in beagle dog after oral administration of from A. de... |
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[Determination of acetylharpagide in Ajuga decumbens by HPLC].
Zhongguo Zhong Yao Za Zhi 31(4) , 289-90, (2006) To establish a method of the quantitative determination of acetylharpagide in Ajuga decumbens.The chromatographic conditions were as follows: a Phenomenex Luna C18 column was used, the mobile phase was composed of acetontrile-water (15:85), the flow rate was ... |
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[Studies on chemical constituents of Galeopsis bifida].
Zhongguo Zhong Yao Za Zhi 27(3) , 206-8, (2002) To investigate the chemical constituents of Galeopsis bifida.Various chromatographic techniques were employed for isolation and purification of the constituents. The structures were elucidated by chemical and spectral analyses.Ten compounds were isolated and ... |
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Vasoconstrictor activity of 8-O-acetylharpagide from Ajuga reptans.
J. Nat. Prod. 55(8) , 1145-8, (1992) The traditional therapeutic indications for the use of Ajuga reptans (Labiatae) have been investigated. The H2O-soluble part of a crude and partially purified MeOH extract and two isolated iridoids (8-O-acetylharpagide and harpagide), were tested for a biolog... |
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Iridoids as allelochemicals and DNA polymerase inhibitors.
J. Nat. Prod. 67(3) , 357-61, (2004) Growth inhibitory activities and nutritional indices of catalpol (1), 8-O-acetylharpagide (2), and harpagide (3) were determinated in larvae and adults of Tribolium castaneum, respectively. Compound 1 produced a series of allelochemical effects probably relat... |
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Cancer chemopreventive activity of an iridoid glycoside, 8-acetylharpagide, from Ajuga decumbens.
Cancer Lett. 157(1) , 87-92, (2000) In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Labiatae plants were screened. Consequently, the iridoid glycoside derivative, 8-acetylharpagide (8-AcHarp), was obtained from the flowering ... |
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8-O-acetylharpagide is a nonsteroidal ecdysteroid agonist.
Insect Biochem. Mol. Biol. 26(6) , 519-23, (1996) We have identified a novel nonsteroidal ecdysteroid agonist. This compound was isolated from a methanol extract of Ajuga reptans L. (Lamiaceae) and the structure was identified by spectroscopic methods as 8-O-acetylharpagide. We have characterised this compou... |
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Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens Thunb extract in rats.
J. Ethnopharmacol. 147(2) , 503-8, (2013) Ajuga decumbens Thunb is a medicinal plant native to China popularly used to treat chronic pelvic inflammation and hysteromyoma. Its main bioactive components are iridoid glycosides, such as 8-O-acetylharpagide and harpagide that had presented antibacterial, ... |
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8-O-acetylharpagide is not an ecdysteroid agonist.
Insect Biochem. Mol. Biol. 31(11) , 1077-82, (2001) We have reinvestigated the activity of 8-O-acetylharpagide, an iridoid glucoside, as an ecdysteroid agonist. Elbrecht et al. (Insect Biochem. Mol. Biol. 26 (1996) 519) isolated a preparation of this compound from Ajuga reptans L. and ascribed ecdysteroid agon... |
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Iridoids from Teucrium yemense.
Arch. Pharm. Res. 21(6) , 785-6, (1998) The aerial parts of Teucrium yemense yielded two iridoid glycosides. Their structures were elucidated by spectral means as teucardosid and 8-O-acetylharpagid. |