4-三氟甲基肉桂酸
4-三氟甲基肉桂酸结构式
|
常用名 | 4-三氟甲基肉桂酸 | 英文名 | trans-4-(Trifluoromethyl)cinnamic acid |
|---|---|---|---|---|
| CAS号 | 16642-92-5 | 分子量 | 216.157 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 279.2±35.0 °C at 760 mmHg | |
| 分子式 | C10H7F3O2 | 熔点 | 231-233 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 122.6±25.9 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
|
Investigation of the influence of CYP1A2 and CYP2C19 genetic polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) pharmacokinetics in leflunomide-treated patients with rheumatoid arthritis.
Drug Metab. Dispos. 37(10) , 2061-8, (2009) Leflunomide is a disease-modifying antirheumatic drug used for the treatment of rheumatoid arthritis (RA). Cytochromes P450, mainly CYP1A2 and CYP2C19, may be involved in the transformation of leflunomide to leflunomide metabolite (A77 1726, 2-cyano-3-hydroxy... |
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