trans-4-(Trifluoromethyl)cinnamic acid
trans-4-(Trifluoromethyl)cinnamic acid structure
|
Common Name | trans-4-(Trifluoromethyl)cinnamic acid | ||
|---|---|---|---|---|
| CAS Number | 16642-92-5 | Molecular Weight | 216.157 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 279.2±35.0 °C at 760 mmHg | |
| Molecular Formula | C10H7F3O2 | Melting Point | 231-233 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 122.6±25.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Investigation of the influence of CYP1A2 and CYP2C19 genetic polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) pharmacokinetics in leflunomide-treated patients with rheumatoid arthritis.
Drug Metab. Dispos. 37(10) , 2061-8, (2009) Leflunomide is a disease-modifying antirheumatic drug used for the treatment of rheumatoid arthritis (RA). Cytochromes P450, mainly CYP1A2 and CYP2C19, may be involved in the transformation of leflunomide to leflunomide metabolite (A77 1726, 2-cyano-3-hydroxy... |
Journals:
More...