L-(+)-2-AMINO-6-PHOSPHONOHEXANOIC ACID
L-(+)-2-AMINO-6-PHOSPHONOHEXANOIC ACID结构式
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常用名 | L-(+)-2-AMINO-6-PHOSPHONOHEXANOIC ACID | 英文名 | L-(+)-2-AMINO-6-PHOSPHONOHEXANOIC ACID |
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| CAS号 | 126253-57-4 | 分子量 | 211.153 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 479.3±55.0 °C at 760 mmHg | |
| 分子式 | C6H14NO5P | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 243.6±31.5 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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The lathyrus toxin, beta-N-oxalyl-L-alpha,beta-diaminopropionic acid (ODAP), and homocysteic acid sensitize CA1 pyramidal neurons to cystine and L-2-amino-6-phosphonohexanoic acid.
Toxicol. Appl. Pharmacol. 219 , 1-9, (2007) A brief exposure of hippocampal slices to L-quisqualic acid (QUIS) sensitizes CA1 pyramidal neurons 30- to 250-fold to depolarization by certain excitatory amino acids analogues, e.g., L-2-amino-6-phosphonohexanoic acid (L-AP6), and by the endogenous compound... |
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L-Quisqualic acid transport into hippocampal neurons by a cystine-sensitive carrier is required for the induction of quisqualate sensitization.
Neuroscience 106 , 287-301, (2001) A brief exposure of hippocampal slices to L-quisqualic acid sensitizes CA1 pyramidal neurons 30-250-fold to depolarization by two classes of excitatory amino acid analogues: (1) those whose depolarizing effects are rapidly terminated following washout, e.g. L... |
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Utilization of the resolved L-isomer of 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.
Brain Res. 649 , 203-207, (1994) Brief exposure of rat hippocampal slices to quisqualic acid (QUIS) sensitizes neurons to depolarization by the alpha-amino-omega-phosphonate excitatory amino acid (EAA) analogues AP4, AP5 and AP6. These phosphonates interact with a novel QUIS-sensitized site.... |