MJN110
MJN110结构式
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常用名 | MJN110 | 英文名 | MJN110 |
|---|---|---|---|---|
| CAS号 | 1438416-21-7 | 分子量 | 462.32600 | |
| 密度 | 1.47±0.1 g/cm3 | 沸点 | 561.5±60.0 °C | |
| 分子式 | C22H21Cl2N3O4 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
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Effect of selective inhibition of monoacylglycerol lipase (MAGL) on acute nausea, anticipatory nausea, and vomiting in rats and Suncus murinus.
Psychopharmacol. Ser. 232(3) , 583-93, (2015) To determine the role of the endocannabinoid, 2-arachodonyl glycerol (2-AG), in the regulation of nausea and vomiting.We evaluated the effectiveness of the potent selective monoacylglycerol lipase (MAGL) inhibitor, MJN110, which selectively elevates the endoc... |
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Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition.
ACS Chem. Biol. , (2013) Serine hydrolases are one of the largest and most diverse enzyme classes in Nature. Inhibitors of serine hydrolases are used to treat many diseases, including obesity, diabetes, cognitive dementia, and bacterial and viral infections. Nonetheless, the majority... |
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Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors.
ACS Chem. Neurosci. 4(9) , 1322-32, (2013) Monoacylglycerol lipase (MAGL) is a principal metabolic enzyme responsible for hydrolyzing the endogenous cannabinoid (endocannabinoid) 2-arachidonoylglycerol (2-AG). Selective inhibitors of MAGL offer valuable probes to further understand the enzyme's functi... |
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The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.
J. Pharmacol. Exp. Ther. 357 , 145-56, (2016) Serious clinical liabilities associated with the prescription of opiates for pain control include constipation, respiratory depression, pruritus, tolerance, abuse, and addiction. A recognized strategy to circumvent these side effects is to combine opioids wit... |