N-甲基靛红酸酐
N-甲基靛红酸酐结构式
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常用名 | N-甲基靛红酸酐 | 英文名 | N-Methylisatoic Anhydride |
|---|---|---|---|---|
| CAS号 | 10328-92-4 | 分子量 | 177.15700 | |
| 密度 | 1.348 g/cm3 | 沸点 | 297.5ºC at 760 mmHg | |
| 分子式 | C9H7NO3 | 熔点 | 165 °C (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 133.7ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Structure and function of echinoderm telomerase RNA.
RNA 22 , 204-15, (2016) Telomerase is a ribonucleoprotein (RNP) enzyme that requires an integral telomerase RNA (TR) subunit, in addition to the catalytic telomerase reverse transcriptase (TERT), for enzymatic function. The secondary structures of TRs from the three major groups of ... |
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Simultaneous determination of myo-inositol and scyllo-inositol by MEKC as a rapid monitoring tool for inositol levels.
Electrophoresis 28(8) , 1221-8, (2007) A simple and rapid MEKC method was developed for the simultaneous determination of myo-inositol, scyllo-inositol, and glucose. Prior to electrophoretic separation, the nonfluorescent inositols and glucose were derivatized by N-methylisatoic anhydride at 25 de... |
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Role of lysine binding residues in the global folding of the lysC riboswitch.
RNA Biol. 12 , 1372-82, (2016) Riboswitches regulate gene expression by rearranging their structure upon metabolite binding. The lysine-sensing lysC riboswitch is a rare example of an RNA aptamer organized around a 5-way helical junction in which ligand binding is performed exclusively thr... |
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RNA structure analysis at single nucleotide resolution by selective 2'-hydroxyl acylation and primer extension (SHAPE).
J. Am. Chem. Soc. 127(12) , 4223-31, (2005) The reactivity of an RNA ribose hydroxyl is shown to be exquisitely sensitive to local nucleotide flexibility because a conformationally constrained adjacent 3'-phosphodiester inhibits formation of the deprotonated, nucleophilic oxyanion form of the 2'-hydrox... |
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RNA SHAPE chemistry reveals nonhierarchical interactions dominate equilibrium structural transitions in tRNA(Asp) transcripts.
J. Am. Chem. Soc. 127(13) , 4659-67, (2005) Current models assume that RNA folding is strongly hierarchical such that the base-paired secondary structure is more stable than and forms independently of the tertiary structure. This model has been difficult to test due to the experimental inability to int... |
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Ligand-dependent folding of the three-way junction in the purine riboswitch.
RNA 14(4) , 675-84, (2008) Riboswitches are highly structured cis-acting elements located in the 5'-untranslated region of messenger RNAs that directly bind small molecule metabolites to regulate gene expression. Structural and biochemical studies have revealed riboswitches experience ... |
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Influence of nucleotide identity on ribose 2'-hydroxyl reactivity in RNA.
RNA 15(7) , 1314-21, (2009) Hydroxyl-selective electrophiles, including N-methylisatoic anhydride (NMIA) and 1-methyl-7-nitroisatoic anhydride (1M7), are broadly useful for RNA structure analysis because they react preferentially with the ribose 2'-OH group at conformationally unconstra... |
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Fingerprinting noncanonical and tertiary RNA structures by differential SHAPE reactivity.
J. Am. Chem. Soc. 134(32) , 13160-3, (2012) Many RNA structures are composed of simple secondary structure elements linked by a few critical tertiary interactions. SHAPE chemistry has made interrogation of RNA dynamics at single-nucleotide resolution straightforward. However, de novo identification of ... |
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Isoenergetic penta- and hexanucleotide microarray probing and chemical mapping provide a secondary structure model for an RNA element orchestrating R2 retrotransposon protein function.
Nucleic Acids Res. 36(6) , 1770-82, (2008) LNA (locked nucleic acids, i.e. oligonucleotides with a methyl bridge between the 2' oxygen and 4' carbon of ribose) and 2,6-diaminopurine were incorporated into 2'-O-methyl RNA pentamer and hexamer probes to make a microarray that binds unpaired RNA approxim... |
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Interaction of N-methyl-anthraniloyl-labelled porcine apolipoprotein A-I with porcine lecithin: cholesterol acyltransferase: an energy transfer study.
Int. J. Biochem. 25(4) , 505-11, (1993) 1. To investigate whether a direct protein-protein interaction between apoA-I and lecithin:cholesterol acyltransferase (LCAT) is necessary for the activation of the enzyme, apoA-I was labelled with N-methylisatoic anhydride at lysine residues. The intermolecu... |