N-Methylisatoic Anhydride

Modify Date: 2025-08-24 19:38:47

N-Methylisatoic Anhydride structure	Common Name	N-Methylisatoic Anhydride
	CAS Number	10328-92-4	Molecular Weight	177.15700
	Density	1.348 g/cm3	Boiling Point	297.5ºC at 760 mmHg
	Molecular Formula	C₉H₇NO₃	Melting Point	165 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	133.7ºC
	Symbol	GHS07	Signal Word	Warning

Use of N-Methylisatoic Anhydride

N-Methylisatoic anhydride (NMIA) is a 2'-OH selective acylation agent of RNAs, and is widely used forresolving secondary RNA structures using the SHAPE (Selective 2'-Hydroxyl Acylation Analyzed by Primer Extension) technology[1].

Name	N-methylisatoic anhydride
Synonym	More Synonyms

Description	N-Methylisatoic anhydride (NMIA) is a 2'-OH selective acylation agent of RNAs, and is widely used forresolving secondary RNA structures using the SHAPE (Selective 2'-Hydroxyl Acylation Analyzed by Primer Extension) technology[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Ursuegui S, et al. Biotin-conjugated N-methylisatoic anhydride: a chemical tool for nucleic acid separation by selective 2'-hydroxyl acylation of RNA. Chem Commun (Camb). 2014 Jun 1;50(43):5748-51.

Density	1.348 g/cm3
Boiling Point	297.5ºC at 760 mmHg
Melting Point	165 °C (dec.)(lit.)
Molecular Formula	C₉H₇NO₃
Molecular Weight	177.15700
Flash Point	133.7ºC
Exact Mass	177.04300
PSA	52.21000
LogP	0.49170
Vapour density	6.1 (vs air)
Vapour Pressure	0.00135mmHg at 25°C
Index of Refraction	1.583
Storage condition	-20°C

N-Methylisatoic Anhydride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DM3140000

CHEMICAL NAME :: 2H-3,1-Benzoxazine-2,4(1H)-dione, 1-methyl-

CAS REGISTRY NUMBER :: 10328-92-4

BEILSTEIN REFERENCE NO. :: 0383957

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H7-N-O3

MOLECULAR WEIGHT :: 177.17

WISWESSER LINE NOTATION :: T66 BNVOVJ B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 34800 mg/kg

SEX/DURATION :: male 8 day(s) pre-mating female 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 15,7,1966

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DM3140000
HS Code	2934999090

Precursor 10
CAS#:118-48-9 Isatoic anhydride CAS#:74-88-4 methyl iodide CAS#:201230-82-2 carbon monoxide CAS#:100-61-8 N-Methylaniline
CAS#:77-78-1 Dimethyl sulfate CAS#:118-92-3 Anthranilic acid CAS#:2058-74-4 1-methylisatin CAS#:119-68-6 N-Methylanthran...
CAS#:79-22-1 Methyl chloroformate CAS#:541-41-3 Ethyl chloroformate
DownStream 10
CAS#:108325-70-8 2-(hydroxymethy... CAS#:1104466-39-8 4-Hydroxy-1-met... CAS#:35472-56-1 Ethyl 2-(methyl... CAS#:81235-51-0 1-methyl-2,2-di...
CAS#:19050-63-6 2-METHYLAMINO-N... CAS#:21097-36-9 1-methyl-3-phen... CAS#:91-22-5 leucoline CAS#:719-54-0 9(10H)-Acridino...
CAS#:84088-42-6 Roquinimex CAS#:85-91-6 methyl n-methyl...

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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1-Methyl-1H-benzo[d][1,3]oxazine-2,4-dione

N-Methylisatoic Anhydride

MFCD00006815

1-methyl-3,1-benzoxazine-2,4-dione

EINECS 233-714-8

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