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10328-92-4

10328-92-4 structure
10328-92-4 structure
  • Name: N-Methylisatoic Anhydride
  • Chemical Name: N-methylisatoic anhydride
  • CAS Number: 10328-92-4
  • Molecular Formula: C9H7NO3
  • Molecular Weight: 177.15700
  • Catalog: Chemical reagent Organic reagent Aromatic acid
  • Create Date: 2018-05-17 08:00:00
  • Modify Date: 2025-08-24 19:38:47
  • N-Methylisatoic anhydride (NMIA) is a 2'-OH selective acylation agent of RNAs, and is widely used forresolving secondary RNA structures using the SHAPE (Selective 2'-Hydroxyl Acylation Analyzed by Primer Extension) technology[1].
Name N-methylisatoic anhydride
Synonyms 1-Methyl-1H-benzo[d][1,3]oxazine-2,4-dione
N-Methylisatoic Anhydride
MFCD00006815
1-methyl-3,1-benzoxazine-2,4-dione
EINECS 233-714-8
Description N-Methylisatoic anhydride (NMIA) is a 2'-OH selective acylation agent of RNAs, and is widely used forresolving secondary RNA structures using the SHAPE (Selective 2'-Hydroxyl Acylation Analyzed by Primer Extension) technology[1].
Related Catalog
References

[1]. Ursuegui S, et al. Biotin-conjugated N-methylisatoic anhydride: a chemical tool for nucleic acid separation by selective 2'-hydroxyl acylation of RNA. Chem Commun (Camb). 2014 Jun 1;50(43):5748-51.
Density 1.348 g/cm3
Boiling Point 297.5ºC at 760 mmHg
Melting Point 165 °C (dec.)(lit.)
Molecular Formula C9H7NO3
Molecular Weight 177.15700
Flash Point 133.7ºC
Exact Mass 177.04300
PSA 52.21000
LogP 0.49170
Vapour density 6.1 (vs air)
Vapour Pressure 0.00135mmHg at 25°C
Index of Refraction 1.583
Storage condition -20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DM3140000
CHEMICAL NAME :
2H-3,1-Benzoxazine-2,4(1H)-dione, 1-methyl-
CAS REGISTRY NUMBER :
10328-92-4
BEILSTEIN REFERENCE NO. :
0383957
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C9-H7-N-O3
MOLECULAR WEIGHT :
177.17
WISWESSER LINE NOTATION :
T66 BNVOVJ B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
34800 mg/kg
SEX/DURATION :
male 8 day(s) pre-mating female 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 15,7,1966
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS DM3140000
HS Code 2934999090
HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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