巴洛沙星
巴洛沙星结构式
|
常用名 | 巴洛沙星 | 英文名 | Balofloxacin |
|---|---|---|---|---|
| CAS号 | 127294-70-6 | 分子量 | 389.42 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 608.3±55.0 °C at 760 mmHg | |
| 分子式 | C20H24FN3O4 | 熔点 | 137ºC | |
| MSDS | 美版 | 闪点 | 321.7±31.5 °C |
|
Determination of the new fluoroquinolone balofloxacin and its metabolites in biological fluids by high performance liquid chromatography.
Arzneimittelforschung 45(6) , 716-8, (1995) A sensitive high performance liquid chromatographic method for the determination in biological fluids of 1-cyclopropyl-6-fluoro-1,4- dihydro-8-methoxy-7-(3-methylaminopiperidin-1-yl)-4-oxoquinoline-3 -carboxylic acid dihydrate (CAS 127294-70-6, balofloxacin, ... |
|
|
Photoallergenicity of a fluoroquinolone antibacterial agent with a fluorine substituent at the 8-position in guinea pigs exposed to long-wavelength UV light.
Skin Pharmacol. Appl. Skin Physiol. 11(4-5) , 232-40, (1998) The 8-position of the quinolone ring of balofloxacin (BLFX), one of fluoroquinolones, was replaced with fluorine to obtain the 8-F. When an aqueous solution of bovine serum albumin (BSA) containing the 8-F was exposed to long-wavelength UV light (UVA) at a ra... |
|
|
Gatifloxacin, moxifloxacin, and balofloxacin resistance due to mutations in the gyrA and parC genes of Staphylococcus epidermidis strains isolated from patients with endophthalmitis, corneal ulcers and conjunctivitis.
Ophthalmic Res. 42(1) , 43-8, (2009) Staphylococcus epidermidis is considered a commensal bacterium; however, it is frequently isolated from ocular infections showing a multidrug resistance. Ciprofloxacin-resistant strains have been isolated from ocular infections; however, resistance to quinolo... |
|
|
Alterations of protein complexes and pathways in genetic information flow and response to stimulus contribute to Escherichia coli resistance to balofloxacin.
Mol. Biosyst. 8(9) , 2303-11, (2012) Protein-protein interactions are important biological processes and essential for a global understanding of cell functions. To date, little is known about the protein interactions and roles of the protein interacting networks and protein complexes in bacteria... |
|
|
High performance liquid chromatography-electrospray ionization mass spectrometric determination of balofloxacin in human plasma and its pharmacokinetics.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 850(1-2) , 68-73, (2007) A selective and sensitive high performance liquid chromatography-electrospray ionisation-mass spectrometry method has been developed for the determination of balofloxacin (BLFX) in human plasma. The sample preparation was a liquid-liquid extraction, and chrom... |
|
|
In vitro and in vivo antibacterial activities of Q-35, a novel fluoroquinolone.
Chemotherapy 41(2) , 100-12, (1995) Q-35, a new fluoroquinolone, was evaluated for its in vitro and in vivo antibacterial activities. In vitro antibacterial activity against gram-positive bacteria was almost equal to that of sparfloxacin or tosufloxacin, but its activity against gram-negative b... |
|
|
[Studies on the reaction of balofloxacin with bovine serum albumin].
Guang Pu Xue Yu Guang Pu Fen Xi 26(8) , 1494-8, (2006) In the present paper, a fluorescence method was used to study at different pH the fluorescence quenching of bovine serum albumin (BSA) by its interaction with balofloxacin (BLFX). The interaction association constants of BSA and BLFX were determined from a do... |
|
|
Flush induced by fluoroquinolones in canine skin.
Inflamm. Res. 44(11) , 461-5, (1995) The flush induced by two fluoroquinolone antibacterial agents, balofloxacin and ofloxacin, was studied in beagle dogs. Intradermal injection of the fluoroquinolones at concentrations above 10(-5) M produced a localized flushed area. The flush responses to flu... |
|
|
Electrophysiological safety of novel fluoroquinolone antibiotic agents gemifloxacin and balofloxacin.
Drug Chem. Toxicol. 29(3) , 303-12, (2006) Some fluoroquinolones have been reported to induce QT interval prolongation associated with the onset of torsades de pointes (TdP), resulting in a life-threatening ventricular arrhythmia. We investigated the cardiac electrophysiological effects of two new flu... |
|
|
Effect of pyridone carboxylic acid anti-microbials on the generation of reactive oxygen species in vitro.
J. Int. Med. Res. 24(4) , 345-51, (1996) The effects of ofloxacin, ciprofloxacin and balofloxacin on the reactive oxygen species (ROS) levels generated by human neutrophils was examined in vitro; ROS generated in a cell-free, xanthine-xanthine oxidase system was also assessed. The species investigat... |