雷莫拉宁
雷莫拉宁结构式
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常用名 | 雷莫拉宁 | 英文名 | ramoplanin A2 |
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| CAS号 | 76168-82-6 | 分子量 | 2554.066 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C106H170ClN21O30 | 熔点 | >218 °C(dec.) | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS05 |
信号词 | Danger |
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Functional identification of the gene encoding the enzyme involved in mannosylation in ramoplanin biosynthesis in Actinoplanes sp.
Biotechnol. Lett. 35(9) , 1501-8, (2013) Ramoplanin is a lipopeptide antibiotic active against multi-drug-resistant, Gram-positive pathogens. Structurally, it contains a di-mannose moiety attached to the peptide core at Hpg(11). The biosynthetic gene cluster of ramoplanin has already been reported a... |
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Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics.
J. Am. Chem. Soc. 126(24) , 7462-3, (2004) Ramoplanin is a potent cyclic lipoglycodepsipeptide antibiotic that disrupts bacterial cell wall synthesis by binding to the peptidoglycan intermediate Lipid II and blocking its polymerization to form the carbohydrate chains of peptidoglycan. Although ramopla... |
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Total synthesis and examination of three key analogues of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity.
J. Am. Chem. Soc. 126(4) , 1041-3, (2004) The total synthesis and evaluation of three key ramoplanin aglycon analogues are detailed. The first (5a) represents replacement of the labile depsipeptide ester with a stable amide (HAsn2 --> Dap2) with removal of the HAsn pendant carboxamide, and it was fou... |
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The mechanism of action of ramoplanin and enduracidin.
Mol. Biosyst. 2(1) , 69-76, (2006) The lipoglycodepsipeptide antibiotic ramoplanin is proposed to inhibit bacterial cell wall biosynthesis by binding to intermediates along the pathway to mature peptidoglycan, which interferes with further enzymatic processing. Two sequential enzymatic steps c... |
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Synthesis and preliminary biological characterization of new semisynthetic derivatives of ramoplanin.
J. Med. Chem. 50(13) , 3077-85, (2007) Ramoplanin is a glycolipodepsipeptide antibiotic active against Gram-positive bacteria including vancomycin-resistant enterococci. Ramoplanin inhibits bacterial cell wall biosynthesis by a mechanism different from that of glycopeptides and hence does not show... |
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Antibiotic action and peptidoglycan formation on tethered lipid bilayer membranes.
Angew. Chem. Int. Ed. Engl. 45(13) , 2111-6, (2006)
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Chemistry and biology of the ramoplanin family of peptide antibiotics.
Biopolymers 66(4) , 261-84, (2002) The peptide antibiotic ramoplanin factor A2 is a promising clinical candidate for treatment of Gram-positive bacterial infections that are resistant to antibiotics such as glycopeptides, macrolides, and penicillins. Since its discovery in 1984, no clinical or... |
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Enduracidin analogues with altered halogenation patterns produced by genetically engineered strains of Streptomyces fungicidicus.
J. Nat. Prod. 73(4) , 583-9, (2010) Enduracidins (1, 2) and ramoplanin (3) are structurally and functionally closely related lipodepsipeptide antibiotics. They are active against multi-drug-resistant Gram-positive pathogens, including MRSA. Each peptide contains one chlorinated non-proteinogeni... |
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Efficacy of oral ramoplanin for inhibition of intestinal colonization by vancomycin-resistant enterococci in mice.
Antimicrob. Agents Chemother. 48(6) , 2144-8, (2004) Ramoplanin is a glycolipodepsipeptide antibiotic with activity against gram-positive bacteria that is in clinical trials for prevention of vancomycin-resistant Enterococcus (VRE) bloodstream infections and treatment of Clostridium difficile diarrhea. Orally a... |
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Validation of a bioanalytical method for the quantification of a therapeutic peptide, ramoplanin, in human dried blood spots using LC-MS/MS.
Biomed. Chromatogr. 25(9) , 995-1002, (2011) A method has been developed and validated for the quantification of ramoplanin, a 2554 Da peptide antibiotic, in human dried blood spots using high-performance liquid chromatography with tandem mass spectrometric detection. The validation data meet FDA accept... |