酰化酶
酰化酶结构式
|
常用名 | 酰化酶 | 英文名 | Native Aspergillus melleus Acylase I |
|---|---|---|---|---|
| CAS号 | 9012-37-7 | 分子量 | 537.523 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 813.3±65.0 °C at 760 mmHg | |
| 分子式 | C30H34Cl2N4O | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 445.7±34.3 °C | |
| 符号 |
GHS07, GHS08 |
信号词 | Danger |
|
Structure of a class III engineered cephalosporin acylase: comparisons with class I acylase and implications for differences in substrate specificity and catalytic activity.
Biochem. J. 451(2) , 217-26, (2013) The crystal structure of the wild-type form of glutaryl-7-ACA (7-aminocephalosporanic acid) acylase from Pseudomonas N176 and a double mutant of the protein (H57βS/H70βS) that displays enhanced catalytic efficiency on cephalosporin C over glutaryl-7-aminoceph... |
|
|
Disposition of bisphenol AF, a bisphenol A analogue, in hepatocytes in vitro and in male and female Harlan Sprague-Dawley rats and B6C3F1/N mice following oral and intravenous administration.
Xenobiotica 45 , 811-9, (2015) 1. Bisphenol AF (BPAF) is used as a crosslinking agent for polymers and is being considered as a replacement for bisphenol A (BPA). 2. In this study, comparative clearance and metabolism of BPAF and BPA in hepatocytes and the disposition and metabolism of BPA... |
|
|
Hydrolysis of N-acyl derivatives of alanine and phenylalanine by acylase I and carboxypeptidase.
J. Biol. Chem. 201(2) , 847-56, (1953)
|
|
|
A lepidopteran aminoacylase (L-ACY-1) in Heliothis virescens (Lepidoptera: Noctuidae) gut lumen hydrolyzes fatty acid-amino acid conjugates, elicitors of plant defense.
Insect Biochem. Mol. Biol. 42(1) , 32-40, (2012) Fatty acid-amino acid conjugates (FACs) have been identified in Lepidopteran larvae as elicitors of plant defenses. Plant responses include the production of primary defense compounds and induction of secondary defense strategies including attraction of paras... |
|
|
Alteration of metal ions improves the activity and thermostability of aminoacylase from hyperthermophilic archaeon Pyrococcus horikoshii.
Biotechnol. Lett. 30(9) , 1639-43, (2008) Recombinant L-aminoacylase (PhoACY) from a hyperthermophilic archeon, Pyrococcus horikoshii, is a zinc-containing metalloenzyme. When the zinc was substituted by Mn(2+) or Ni(2+), its specific activity was significantly increased with acetyl-L-methionine as a... |
|
|
Proteomic analysis of nucleopolyhedrovirus infection resistance in the silkworm, Bombyx mori (Lepidoptera: Bombycidae).
J. Invertebr. Pathol. 105(1) , 84-90, (2010) Silkworm hemolymph is an important defense tissue to resist bacteria and virus infections. To study the response of silkworm hemolymph in the resistance of Bombyx mori L. nucleopolyhedrovirus (BmNPV), we constructed a near-isogenic silkworm line with BmNPV re... |
|
|
Differential aminoacylase expression in neuroblastoma.
Int. J. Cancer 129(6) , 1322-30, (2011) Neuroblastoma, a cancer of the sympathetic nervous system, is the most common extracranial solid tumor in children. MYCN amplification and increased BDNF/TrkB signaling are features of high-risk tumors; yet, only ˜25% of malignant tumors display these feature... |
|
|
Engineering the substrate specificity of Alcaligenes D-aminoacylase useful for the production of D-amino acids by optical resolution.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(29) , 3247-52, (2011) D-Aminoacylase from Alcaligenes xylosoxydans subsp. xylosoxydans A-6 (AxD-NAase) offers a novel biotechnological application, the production of D-amino acid from the racemic mixture of N-acyl-DL-amino acids. However, its substrate specificity is biased toward... |
|
|
Mouse aminoacylase 3: a metalloenzyme activated by cobalt and nickel.
Biochim. Biophys. Acta 1794(7) , 1049-57, (2009) Aminoacylase 3 (AA3) deacetylates N-acetyl-aromatic amino acids and mercapturic acids including N-acetyl-1,2-dichlorovinyl-L-cysteine (Ac-DCVC), a metabolite of a xenobiotic trichloroethylene. Previous studies did not demonstrate metal-dependence of AA3 despi... |
|
|
Functional expression of porcine aminoacylase 1 in E. coli using a codon optimized synthetic gene and molecular chaperones.
Appl. Microbiol. Biotechnol. 81(4) , 721-9, (2008) Efficient recombinant expression of N-acyl-L-aminoacylase 1 from pig kidney (pAcy1) was achieved in the prokaryotic host Escherichia coli. An optimized nucleotide sequence (codon adaptation index 0.95 for E. coli), was cloned into vector pET-52(b) yielding an... |