中文名 | 氨基酰化酶 |
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英文名 | Aminoacylase |
中文别名 |
酰化氨基酸水解酶
酰化酶 I 酰基转移酶,从猪肾所得 氨基酰化酶,从曲霉属所得 酰基转移酶I(猪肾) |
英文别名 |
7-[(6,8-Dichloro-1,2,3,4-tetrahydro-9-acridinyl)amino]-N-[2-(1H-indol-3-yl)ethyl]heptanamide
E.C. 3.5.1.14 N-Acyl-L-amino acid amidohydrolase Hippuricase Benzamidase Dehydropeptidase II Aminoacylase I Histozyme Hippurase L-Aminoacylase 7-[(6,8-dichloro-1,2,3,4-tetrahydroacridin-9-yl)amino]-N-[2-(1H-indol-3-yl)ethyl]heptanamide Amino acid deacylase Aminoacylase 1 L-Amino acid acylase Acylase 1500 Amano MFCD00081285 Heptanamide, 7-[(6,8-dichloro-1,2,3,4-tetrahydro-9-acridinyl)amino]-N-[2-(1H-indol-3-yl)ethyl]- Acylase I EINECS 232-732-3 Acylase Native Aspergillus melleus Acylase I |
密度 | 1.3±0.1 g/cm3 |
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沸点 | 813.3±65.0 °C at 760 mmHg |
分子式 | C30H34Cl2N4O |
分子量 | 537.523 |
闪点 | 445.7±34.3 °C |
精确质量 | 536.210938 |
LogP | 7.64 |
外观性状 | 固体;White to Amber powder to crystalline |
蒸汽压 | 0.0±2.9 mmHg at 25°C |
折射率 | 1.668 |
储存条件 | 密封-20℃干燥保存。 |
稳定性 | Analysis Note Protein determined by biuret. Unit Definition One unit will hydrolyze 1.0 μmole of N-acetyl-L-methionine per hr at pH 7.0 at 25 °C. Biochem/physiol Actions The enzyme hydrolyzes a variety of N-acyl-L-amino acids and dehydropeptides containing dehydroalanyl residues. N-acyl-D-amino acids and dehydropeptides other than dehydroalanine are not hydrolyzed. The following compounds are hydrolyzed by acylase I: chloroacetyl-L-amino acids, L-leucinamide, chloroacetyldehydroalanine, glycyl-L-amino acids, and glycyldehydroalanine. Aminoacylase is widely used as a reagent to resolve amino acid racemates. The Km for acyl amino acids have been reported in the literature: Ac-L-Met (0.99 mM), Ac-L-Glu (10.2 mM), and Ac-L-Phe (5.5 mM). Aminoacylase from pig kidney is activated by Zn2+ and Co2+ and inhibited by SH blocking reagents, disulfide reducing reagents, N-tosyl-L-alanine, DL-norleucine, and N-tosyl-L-lysine chloromethylketone. |
计算化学 | 1.疏水参数计算参考值(XlogP):7.6 2.氢键供体数量:3 3.氢键受体数量:3 4.可旋转化学键数量:11 5.互变异构体数量:12 6.拓扑分子极性表面积69.8 7.重原子数量:37 8.表面电荷:0 9.复杂度:726 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1 |
更多 | 1. 性状:浅红色或浅黄色冻干粉。 2. 密度(g/mL,25/4℃):未确定 3. 相对蒸汽密度(g/mL,空气=1):未确定 4. 熔点(ºC):未确定 5. 沸点(ºC,常压):未确定 6. 沸点(ºC, 5.2kPa):未确定 7. 折射率:未确定 8. 闪点(ºC):未确定 9. 比旋光度(º ):未确定 10. 自燃点或引燃温度(ºC):未确定 11. 蒸气压(kPa,25ºC):未确定 12. 饱和蒸气压(kPa,60ºC):未确定 13. 燃烧热(KJ/mol):未确定 14. 临界温度(ºC):未确定 15. 临界压力(KPa):未确定 16. 油水(辛醇/水)分配系数的对数值:未确定 17. 爆炸上限(%,V/V):未确定 18. 爆炸下限(%,V/V):未确定 19. 溶解性:溶于水,最适pH值7.0-7.5(猪肾、淀粉酶)或7-8(米曲酶)。 |
符号 |
GHS07, GHS08 |
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信号词 | Danger |
危害声明 | H315-H319-H334-H335 |
警示性声明 | P261-P305 + P351 + P338-P342 + P311 |
个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
危害码 (欧洲) | Xn |
风险声明 (欧洲) | 36/37/38-42 |
安全声明 (欧洲) | 22-24/25 |
危险品运输编码 | NONH for all modes of transport |
WGK德国 | 3 |
RTECS号 | BF4890000 |