α-半乳糖苷酶
α-半乳糖苷酶结构式
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常用名 | α-半乳糖苷酶 | 英文名 | α-galactosidase |
|---|---|---|---|---|
| CAS号 | 9025-35-8 | 分子量 | 192.602 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 324.4±22.0 °C at 760 mmHg | |
| 分子式 | C9H5ClN2O | 熔点 | N/A | |
| MSDS | N/A | 闪点 | 150.0±22.3 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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High throughput screening for inhibitors of alpha-galactosidase.
Curr. Chem. Genomics 4 , 67-73, (2011) Fabry disease is a rare X-linked lysosomal storage disorder caused by a deficiency in α-galactosidase A (GLA), which catalyzes the hydrolysis of terminal α-galactosyl groups from glycosphingolipids, such as globotriaosylceramide (Gb3). Many of the mutations i... |
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Endothelial nitric oxide synthase uncoupling and microvascular dysfunction in the mesentery of mice deficient in α-galactosidase A.
Am. J. Physiol. Gastrointest. Liver Physiol. 306(2) , G140-6, (2014) A defect in the gene for the lysosomal enzyme α-galactosidase A (Gla) results in globotriaosylceramide (Gb3) accumulation in Fabry disease and leads to premature death from cardiac and cerebrovascular events. However, gastrointestinal symptoms are often first... |
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Long-term effect of antibodies against infused alpha-galactosidase A in Fabry disease on plasma and urinary (lyso)Gb3 reduction and treatment outcome.
PLoS ONE 7(10) , e47805, (2012) Enzyme replacement therapy (ERT) with alpha-Galactosidase A (aGal A) may cause antibody (AB) formation against aGal A in males with Fabry disease (FD). Anti agalsidase ABs negatively influence globotriaosylceramide (Gb3) reduction. We investigated the impact ... |
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Cicer α-galactosidase immobilization onto functionalized graphene nanosheets using response surface method and its applications.
Food Chem. 142 , 430-8, (2014) Cicer α-galactosidase was immobilized onto functionalized graphene with immobilization efficiency of 84% using response surface methodology (Box-Behnken design). The immobilized enzyme had higher thermal stability than the soluble one, attractive for industri... |
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Fabry's disease--a comprehensive review on pathogenesis, diagnosis and treatment.
J. Pak. Med. Assoc. 64(2) , 189-94, (2014) Fabry's is a progressive, destructive and life threatening disease which reduces significantly life expectancy of the affected individual. It is a genetic disorder of X-linked inheritance caused by deficiency of lysosomal enzyme alpha-galactosidase A resultin... |
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Angiokeratomas - When is a few too many?
Int. J. STD AIDS 25(5) , 378-9, (2014) Many patients have a few scattered angiokeratoma and we reassure them that this it is normal; however, if they are numerous, Fabry disease should be considered and the family history should be checked. |
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Alpha-galactosidase from Mortierella vinacea. Crystallization and properties.
J. Biol. Chem. 245(4) , 781-6, (1970)
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Fabry disease: dose matters.
J. Am. Soc. Nephrol. 25(4) , 653-5, (2014)
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The Ca2+-activated K+ channel of intermediate conductance: a molecular target for novel treatments?
Ann. Allergy Asthma Immunol. 112(1) , 71-2, (2014) This review discusses the Ca2+-activated K+ channels of intermediate conductance (IK channels), and their historical discovery in erythrocytes, their classical biophysical characteristics, physiological function, molecular biology as well as their role as pos... |
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Red meat allergy in Sweden: association with tick sensitization and B-negative blood groups.
J. Allergy Clin. Immunol. 132(6) , 1431-4, (2013)
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