毛地黄毒苷配基
毛地黄毒苷配基结构式
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常用名 | 毛地黄毒苷配基 | 英文名 | Digitoxigenin |
|---|---|---|---|---|
| CAS号 | 143-62-4 | 分子量 | 374.514 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 549.3±50.0 °C at 760 mmHg | |
| 分子式 | C23H34O4 | 熔点 | 253-255 °C (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 188.2±23.6 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Synthesis and evaluation of cardiac glycoside mimics as potential anticancer drugs.
Bioorg. Med. Chem. 19 , 2407-17, (2011) The cardiac glycoside digitoxin, consisting of a steroid core linked to a labile trisaccharide, has been used for centuries for the treatment of congestive heart failure. The well known pharmacological effect is a result of the ability of cardiac glycosides t... |
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C3'/C4'-Stereochemical Effects of Digitoxigenin α-L-/α-D-Glycoside in Cancer Cytotoxicity.
ChemMedChem 8 , 63, (2013) Sweet'n low in stereo: A Wharton reaction was employed along with a diastereoselective palladium-catalyzed glycosylation and other post-glycosylation transformations to synthesize digitoxin analogues. Cytotoxic evaluation against a panel of cancer cell lines ... |
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Assembly of digitoxin by gold(I)-catalyzed glycosidation of glycosyl o-alkynylbenzoates.
J. Org. Chem. 76 , 9748, (2011) Digitoxin, a clinically important cardiac trisaccharide, was assembled efficiently from digitoxigenin and 3,4-di-O-tert-butyldiphenylsilyl-d-digitoxosyl o-cyclopropylethynylbenzoate in 9 steps and 52% overall yield via alternate glycosylation and protecting g... |
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Integrating high-content screening and ligand-target prediction to identify mechanism of action.
Nat. Chem. Biol. 4 , 59-68, (2008) High-content screening is transforming drug discovery by enabling simultaneous measurement of multiple features of cellular phenotype that are relevant to therapeutic and toxic activities of compounds. High-content screening studies typically generate immense... |
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Cardenolide and oxypregnane glycosides from the root of Asclepias incarnata L.
Chem. Pharm. Bull. 48(4) , 516-24, (2000) Twenty-nine new oxypregnane glycosides were obtained along with two known cardenolides, frugoside and gofruside, and three known 12-O-acylated pregnane glycosides from the roots of Asclepias incarnata L. (Asclepiadaceae). By detailed studies of the 1H- and 13... |
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Inhibitory activity of a phytochemically characterized fraction from Streptocaulon juventas on lung cancer in nude mice.
Planta Med. 76(6) , 561-5, (2010) In the present study, a 75% ethanol extract of Streptocaulon juventas (SJ), which had a strong inhibitory effect on the proliferation of human lung A549 adenocarcinoma cells, was subjected to bioassay-guided fractionation. The most active fraction (SJF) was o... |
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Effect of the digitoxigenin derivative, INCICH-D7, on Na+, K+-ATPase.
Biochem. Pharmacol. 70(6) , 851-7, (2005) Compound 14beta,17beta-cycloketoester-3beta-OH androstane (INCICH-D7) is a semisynthetic product of a structural modification of the digitoxigenin molecule. INCICH-D7 has a heterocyclic ketoester type fusion between positions C14 and C17 of the steroid nucleu... |
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Measurement of serum digitoxin in patients by radioimmunoassay using specific antiserum.
Clin. Chim. Acta 314(1-2) , 245-7, (2001) Digitoxin is used to treat patients with heart failure.A radioimmunoassay procedure for the specific determination for digitoxin in serum was developed using the antiserum (antiserum (A)) raised against digitoxin 3'-hemisuccinate-BSA conjugate.The intra- and ... |
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Periplogenin-3-O- -D-glucopyranosyl -(1-->6)- -D-glucopyaranosyl- -(1-->4) -D-cymaropyranoside, isolated from Aegle marmelos protects doxorubicin induced cardiovascular problems and hepatotoxicity in rats.
Cardiovasc. Ther. 27(2) , 108-16, (2009) Doxorubicin is a common chemotherapeutic anticancer drug. Its use is associated with adverse effects including cardiotoxicity. Several therapeutics interventions have been attempted to reduce the toxicity and to improve the efficacy of the drug. However, on p... |
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Synthesis and biological evaluation of 2-hydroxy derivatives of digitoxigenin and 3-epidigitoxigenin.
Bioorg. Med. Chem. 6(10) , 1889-94, (1998) The four stereoisomers of the 2-hydroxy derivatives of digitoxigenin and 3-epidigitoxigenin have been synthesized, their structures established by NMR, and their binding affinity for the digitalis receptor on Na+, K(+)-ATPase evaluated. These derivatives show... |