荧光素
荧光素结构式
|
常用名 | 荧光素 | 英文名 | Fluorescein |
|---|---|---|---|---|
| CAS号 | 2321-07-5 | 分子量 | 332.306 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | 620.8±55.0 °C at 760 mmHg | |
| 分子式 | C20H12O5 | 熔点 | 320 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 232.6±25.0 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
|
CPEB1 modulates differentiation of glioma stem cells via downregulation of HES1 and SIRT1 expression.
Oncotarget 5(16) , 6756-69, (2014) Glioma stemness has been recognized as the most important reason for glioma relapse and drug resistance. Differentiation of glioma stem cells (GSCs) has been implicated as a novel approach to target recurrent glioma. However, the detailed molecular mechanism ... |
|
|
Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption.
PLoS ONE 9(7) , e101824, (2014) Desmosomes are perturbed in a number of disease states - including genetic disorders, autoimmune and bacterial diseases. Here, we report unexpected changes in other cell-cell adhesion structures upon loss of desmosome function. We found that perturbation of d... |
|
|
Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease.
Brain Behav. 3(2) , 75-88, (2013) Cerebral dopamine neurotrophic factor (CDNF) protein has been shown to protect the nigrostriatal dopaminergic pathway when given as intrastriatal infusions in rat and mouse models of Parkinson's disease (PD). In this study, we assessed the neuroprotective eff... |
|
|
Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS.
J. Immunol. 194(4) , 1545-54, (2015) Rapid and robust induction of type I IFN (IFN-I) is a critical event in host antiviral innate immune response. It has been well demonstrated that cyclic GMP-AMP (cGAMP) synthase (cGAS) plays an important role in sensing cytosolic DNA and triggering STING depe... |
|
|
Enhanced Retinal Ganglion Cell Survival in Glaucoma by Hypoxic Postconditioning After Disease Onset.
Neurotherapeutics 12(2) , 502-14, (2015) The neuroprotective efficacy of adaptive epigenetics, wherein beneficial gene expression changes are induced by nonharmful "conditioning" stimuli, is now well established in several acute, preclinical central nervous system injury models. Recently, in a mouse... |
|
|
Proteolysis of decellularized extracellular matrices results in loss of fibronectin and cell binding activity.
Biochem. Biophys. Res. Commun. 459(2) , 246-51, (2015) Excessive inflammation in the chronic wound bed is believed to result in increased fibronectin (FN) proteolysis and poor tissue repair. However, FN fragments can prime the immune response and result in higher protease levels. The reciprocity between FN proteo... |
|
|
CARD3 deficiency protects against colitis through reduced epithelial cell apoptosis.
Inflamm. Bowel Dis. 21(4) , 862-9, (2015) Caspase activation and recruitment domain 3 (CARD3) is a 61-kDa protein kinase. Recent evidence shows the importance of CARD3 in the immune response and inflammatory diseases. To elucidate its impact on inflammatory bowel disease, we studied the effects of th... |
|
|
NFIL3 suppresses hypoxia-induced apoptotic cell death by targeting the insulin-like growth factor 2 receptor.
J. Cell. Biochem. 116(6) , 1113-20, (2015) The insulin-like growth factor-II/mannose 6-phosphate receptor (IGF2R) over-expression correlates with heart disease progression. The IGF2R is not only an IGF2 clearance receptor, but it also triggers signal transduction, resulting in cardiac hypertrophy, apo... |
|
|
XAV939 inhibits the stemness and migration of neuroblastoma cancer stem cells via repression of tankyrase 1.
Int. J. Oncol. 45(1) , 121-8, (2014) Neuroblastoma (NB) is the most common extracranial solid tumor in childhood. One fundamental issue regarding NB recurrence and metastasis is the maintenance of cancer stem cells (CSCs) stemness. Tankyrase 1 (TNKS1) is overexpressed in several types of cancers... |
|
|
Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases.
Nat. Commun. 6 , 6119, (2015) Toll-like receptor 7 (TLR7) senses microbial-derived RNA but can also potentially respond to self-derived RNA. To prevent autoimmune responses, TLR7 is thought to localize in endolysosomes. Contrary to this view, we show here that TLR7 is present on the cell ... |