Fluorescein

Modify Date: 2024-01-02 10:37:38

Fluorescein structure	Common Name	Fluorescein
	CAS Number	2321-07-5	Molecular Weight	332.306
	Density	1.6±0.1 g/cm3	Boiling Point	620.8±55.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₁₂O₅	Melting Point	320 °C(lit.)
	MSDS	Chinese USA	Flash Point	232.6±25.0 °C
	Symbol	GHS07	Signal Word	Warning

Use of Fluorescein

Fluorescein is a synthetic fluorescent tracer.

Name	fluorescein
Synonym	More Synonyms

Description	Fluorescein is a synthetic fluorescent tracer.
Related Catalog	Signaling Pathways >> Others >> Others Dye Reagents Research Areas >> Others
In Vitro	The fluorescein dye is a common fluorescent probe. Its very high molar absorptivity at the wavelength of the argon laser (488 nm), large fluorescence quantum yield and high photostability makes it a very useful and sensitive fluorescent label. Fluorescein is commercially available in many derivatives, such as fluorescein isothiocyanate and fluorescein succinimidyl ester, that can be covalently attached to macromolecules and to amino acids. The labeled molecules can be detected with very high sensitivity which is utilized in, for example, capillary electrophoresis. The emission spectrum of fluorescein overlaps extensively the absorption spectrum of tetramethyl rhodamine, which is a related strongly fluorescent dye, making this pair very suitable for energy transfer experiments to determine distances within and between labeled macromolecules. Fluorescein in aqueous solution occurs in cationic, neutral, anionic and dianionic forms making its absorption and fluoresence properties strongly pH dependent[1].
References	[1]. R Sjöback, et al. Absorption and fluorescence properties of fluorescein. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Density	1.6±0.1 g/cm3
Boiling Point	620.8±55.0 °C at 760 mmHg
Melting Point	320 °C(lit.)
Molecular Formula	C₂₀H₁₂O₅
Molecular Weight	332.306
Flash Point	232.6±25.0 °C
Exact Mass	332.068481
PSA	87.74000
LogP	2.98
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.792
Storage condition	−20°C
Water Solubility	insoluble

Fluorescein MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LM5075000

CHEMICAL NAME :: Fluorescein

CAS REGISTRY NUMBER :: 2321-07-5

BEILSTEIN REFERENCE NO. :: 0094324

LAST UPDATED :: 199707

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C20-H12-O5

MOLECULAR WEIGHT :: 332.32

WISWESSER LINE NOTATION :: T C666 BO EVJ IR BVQ& MQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 15 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 33350 No. of Facilities: 495 (estimated) No. of Industries: 18 No. of Occupations: 21 No. of Employees: 5188 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 33350 No. of Facilities: 2171 (estimated) No. of Industries: 42 No. of Occupations: 55 No. of Employees: 88495 (estimated) No. of Female Employees: 21558 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi:Irritant;
Risk Phrases	R36;R43
Safety Phrases	S22-S24/25-S37/39-S26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LM5075000
Packaging Group	I; II; III
HS Code	3204200000

Precursor 8
CAS#:596-09-8 Fluorescein Dia... CAS#:85-44-9 Phthalic anhydride CAS#:108-46-3 Resorcine CAS#:3326-31-6 6-FITC
CAS#:3326-34-9 5-Aminofluorescein CAS#:108-95-2 Phenol CAS#:89-84-9 2,4-Dihydroxyac... CAS#:83616-10-8 FLUORESCEIN MON...
DownStream 9
CAS#:3326-32-7 Fluorescein iso... CAS#:36886-76-7 3',6'-DIMETHOXY... CAS#:2861-41-8 2',4',5'-trichl... CAS#:2320-38-9 2',4',5',7'-tet...
CAS#:24545-86-6 4',5'-DINITROFL... CAS#:25709-83-5 Spiroisobenzofu... CAS#:2513-33-9 2-(2,4-Dihydrox... CAS#:108-46-3 Resorcine
CAS#:65-85-0 benzoic acid

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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D and C Yellow No. 7

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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Fluorescein
Price: ￥778.0/500g ￥218.0/100g ￥78.0/25g ￥1288.0/1kg
Purity: 90.0%
Stocking Period: Inquiry
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Fluorescein
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Fluorescein
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: fluorescein
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Fluorescein

Use of Fluorescein

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Fluorescein Biological Activity

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MSDS

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HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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