3326-34-9

3326-34-9 structure

Name: 5-Aminofluorescein
Chemical Name: 6-amino-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
CAS Number: 3326-34-9
Molecular Formula: C₂₀H₁₃NO₅
Molecular Weight: 347.321
Catalog: analytical chemistry Liquid Chromatography HPLC labeling reagent
Create Date: 2018-02-18 08:00:00
Modify Date: 2025-08-21 14:03:55
5-Aminofluorescein (5-AF) is a new fluorescence marker, covalently bound to human serum albumin (AFL-HSA) [1]5-aminofluorescein is a pH-sensitive biomaterial, is the targeted prodrug for synthesis of FA-FITC-Arg-PTX and FA-5AF- Glu-PTX..

Name	6-amino-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
Synonyms	Fluoresceinamine (isomer I) Fluoresceinamine 1-AMINOFLUORESCEIN 5-Amino-3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthen]-3-one Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 5-amino-3',6'-dihydroxy- 1-FLUORESCEINAMINE EINECS 222-043-6 Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 5-amino-3',6'-dihydroxy- FLUORESCEINAMINE ISOMER I 4-AMINOFLUORESCEIN ISOMER I MFCD00005052 5-Aminofluorescein AMINOFLUORESCEIN 5-Amino-3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthen]-3-on FLUORESCEINAMINE,ISOMER 1 5-fluorescein amine Fluoresceinamine-I 5-Aminofluorescein (isomer I) 4-AMINOFLUORESCEIN Fluoresceinamine,isomer I 5-Amino-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one (isomer I)

Description	5-Aminofluorescein (5-AF) is a new fluorescence marker, covalently bound to human serum albumin (AFL-HSA) [1]5-aminofluorescein is a pH-sensitive biomaterial, is the targeted prodrug for synthesis of FA-FITC-Arg-PTX and FA-5AF- Glu-PTX..
Related Catalog	Signaling Pathways >> Others >> Others Dye Reagents Research Areas >> Others
References	[1]. Ding R, et al. Pharmacokinetics of 5-aminofluorescein-albumin, a novel fluorescence marker of brain tumors during surgery. J Clin Pharmacol. 2011 May;51(5):672-8. [2]. Miao R, et al. Facile method for modification of the silicon nanowires and its application in fabrication of pH-sensitive chips. ACS Appl Mater Interfaces. 2013 Mar 13;5(5):1741-6. [3]. Wang T, et al. Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein. J Am Chem Soc. 2015 Nov 4;137(43):13736-9. [4]. Shan L, et al. Multi-small molecule conjugations as new targeted delivery carriers for tumor therapy. Int J Nanomedicine. 2015 Sep 1;10:5571-91.

Density	1.6±0.1 g/cm3
Boiling Point	695.3±55.0 °C at 760 mmHg
Melting Point	223ºC
Molecular Formula	C₂₀H₁₃NO₅
Molecular Weight	347.321
Flash Point	374.3±31.5 °C
Exact Mass	347.079376
PSA	102.01000
LogP	1.80
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.820
Storage condition	2-8°C
Stability	Light and Moisture Sensitive

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2921199090

3326-35-0

~76%

3326-34-9

Literature: Helvetica Chimica Acta, , vol. 86, # 7 p. 2299 - 2334

610-27-5

3326-34-9

Literature: ACS Medicinal Chemistry Letters, , vol. 3, # 9 p. 774 - 779

108-46-3

3326-34-9

Literature: ACS Medicinal Chemistry Letters, , vol. 3, # 9 p. 774 - 779

14926-29-5

3326-34-9

Literature: ACS Medicinal Chemistry Letters, , vol. 3, # 9 p. 774 - 779

2307-00-8

108-46-3

3326-34-9

51649-83-3

Literature: Russian Journal of General Chemistry, , vol. 65, # 3.2 p. 454 - 456 Zhurnal Obshchei Khimii, , vol. 65, # 3 p. 511 - 513

HS Code	2921199090
Summary	2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%