环亮氨酸
环亮氨酸结构式
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常用名 | 环亮氨酸 | 英文名 | Cycloleucine |
|---|---|---|---|---|
| CAS号 | 52-52-8 | 分子量 | 129.157 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 256.1±23.0 °C at 760 mmHg | |
| 分子式 | C6H11NO2 | 熔点 | 320 °C (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 108.7±22.6 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
J. Med. Chem. 51 , 6740-51, (2008) The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives, and the theoretical pr... |
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In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increase.
J. Neurosci. 33(19) , 8411-22, (2013) Calcium-dependent release of vasoactive gliotransmitters is widely assumed to trigger vasodilation associated with rapid increases in neuronal activity. Inconsistent with this hypothesis, intact stimulus-induced vasodilation was observed in inositol 1,4,5-tri... |
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Drug design, in vitro pharmacology, and structure-activity relationships of 3-acylamino-2-aminopropionic acid derivatives, a novel class of partial agonists at the glycine site on the N-methyl-D-aspartate (NMDA) receptor complex.
J. Med. Chem. 52 , 5093-107, (2009) Retaining agonistic activity at the glycine coagonist site of the NMDA receptor in molecules derived from glycine or d-serine has proven to be difficult because in the vicinity of the alpha-amino acid group little substitution is tolerated. We have solved thi... |
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Quantal amplitude at the cone ribbon synapse can be adjusted by changes in cytosolic glutamate.
Mol. Vis. 17 , 920-31, (2011) Vision is encoded at photoreceptor synapses by the number of released vesicles and size of the post-synaptic response. We hypothesized that elevating cytosolic glutamate could enhance quantal size by increasing glutamate in vesicles.We introduced glutamate (1... |
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Conformations of peptides containing a chiral cyclic α, α-disubstituted α-amino acid within the sequence of Aib residues.
J. Pept. Sci. 16(11) , 621-6, (2010) A single chiral cyclic α,α-disubstituted amino acid, (3S,4S)-1-amino-(3,4-dimethoxy)cyclopentanecarboxylic acid [(S,S)-Ac(5)c(dOM)], was placed at the N-terminal or C-terminal positions of achiral α-aminoisobutyric acid (Aib) peptide segments. The IR and (1)H... |
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Astrocyte inositol triphosphate receptor type 2 and cytosolic phospholipase A2 alpha regulate arteriole responses in mouse neocortical brain slices.
PLoS ONE 7(8) , e42194, (2012) Functional hyperemia of the cerebral vascular system matches regional blood flow to the metabolic demands of the brain. One current model of neurovascular control holds that glutamate released by neurons activates group I metabotropic glutamate receptors (mGl... |
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Involvement of glutamate and cytokine pathways on antinociceptive effect of Pfaffia glomerata in mice.
J. Ethnopharmacol. 122(3) , 468-72, (2009) Pfaffia glomerata (Spreng) Pedersen (Amaranthaceae) is a medicinal plant known in Brazil as "Paratudo" and "Brazilian ginseng" and is commonly used as tonic, antidiabetic and to treat gastric disorders.This study evaluates the possible mechanism by which hydr... |
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Furthering pharmacological and physiological assessment of the glutamatergic receptors at the Drosophila neuromuscular junction.
Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 150(4) , 546-57, (2009) Drosophila melanogaster larval neuromuscular junctions (NMJs) serve as a model for synaptic physiology. The molecular sequences of the postsynaptic glutamate receptors have been described; however, the pharmacological profile has not been fully elucidated. Th... |
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High-performance liquid chromatographic enantioseparation of unusual isoxazoline-fused 2-aminocyclopentanecarboxylic acids on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid-based chiral stationary phases.
Chirality 24(10) , 817-24, (2012) The enantiomers of four unusual isoxazoline-fused 2-aminocyclopentanecarboxylic acids were directly separated on chiral stationary phases containing (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid as chiral selector. The nature of the alcoholic modifier (MeOH... |
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Investigation of the molecular response to folate metabolism inhibition.
J. Nutr. Biochem. 23(11) , 1531-6, (2012) We investigated the molecular response to folate metabolism inhibition by exposing human lymphoblast cell lines to the methionine adenosyltransferase inhibitor cycloleucine. We carried out microarray analysis on replicate control and exposed cells by examinin... |