异氰酸2-溴苯酯
异氰酸2-溴苯酯结构式
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常用名 | 异氰酸2-溴苯酯 | 英文名 | 1-Bromo-2-isocyanatobenzene |
|---|---|---|---|---|
| CAS号 | 1592-00-3 | 分子量 | 198.017 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 281.6±0.0 °C at 760 mmHg | |
| 分子式 | C7H4BrNO | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 92.2±22.6 °C | |
| 符号 |
GHS06, GHS08 |
信号词 | Danger |
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Selective synthesis of a [3]rotaxane consisting of size-complementary components and its stepwise deslippage.
Org. Lett. 14(9) , 2226-9, (2012) An α-cyclodextrin-based size-complementary [3]rotaxane with an alkylene axle was selectively synthesized in one pot via an end-capping reaction with 2-bromophenyl isocyanate in water. Thermal degradation of the [3]rotaxane product yielded not only the origina... |
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Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development.
Bioorg. Med. Chem. Lett. 16(12) , 3287-91, (2006) Small molecule antagonists of the vanilloid receptor TRPV1 (also known as VR1) are disclosed. Pyrrolidinyl ureas such as 8 and 15 (SB-705498) emerged as lead compounds following optimisation of the previously described urea SB-452533. Pharmacological studies ... |
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Discovery of potent and orally bioavailable N,N'-diarylurea antagonists for the CXCR2 chemokine receptor.
Bioorg. Med. Chem. Lett. 14(17) , 4375-8, (2004) A series of 3-substituted N,N'-diarylureas was prepared and the structure-activity relationship relative to CXCR2 receptor affinity as well as their pharmacokinetic properties were examined. In vitro microsomal metabolism studies indicated that the lower clea... |