2-异丙基苹果酸
2-异丙基苹果酸结构式
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常用名 | 2-异丙基苹果酸 | 英文名 | 2-HYDROXY-2-ISOPROPYLSUCCINIC ACID |
|---|---|---|---|---|
| CAS号 | 3237-44-3 | 分子量 | 176.16700 | |
| 密度 | 1.342g/cm3 | 沸点 | 306.4ºC at 760mmHg | |
| 分子式 | C7H12O5 | 熔点 | 144-146ºC(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 153.3ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Identification of putative biomarkers for prediabetes by metabolome analysis of rat models of type 2 diabetes.
Metabolomics 11 , 1277-1286, (2015) Biomarkers for the development of type 2 diabetes (T2D) are useful for prediction and intervention of the disease at earlier stages. In this study, we performed a longitudinal study of changes in metabolites using an animal model of T2D, the spontaneously dia... |
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Human metabolic responses to chronic environmental polycyclic aromatic hydrocarbon exposure by a metabolomic approach.
J. Proteome Res. 14 , 2583-93, (2015) The toxicities of polycyclic aromatic hydrocarbons (PAHs) have been extensively explored due to their carcinogenic and mutagenic potency; however, little is known about the metabolic responses to chronic environmental PAH exposure among the general population... |
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A potential tool for diagnosis of male infertility: Plasma metabolomics based on GC-MS.
Talanta 147 , 82-9, (2015) Male infertility has become an important public health problem worldwide. Nowadays the diagnosis of male infertility frequently depends on the results of semen quality or requires more invasive surgical intervention. Therefore, it is necessary to develop a no... |
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alpha-Isopropylmalate, a leucine biosynthesis intermediate in yeast, is transported by the mitochondrial oxalacetate carrier.
J. Biol. Chem. 283(42) , 28445-53, (2008) In Saccharomyces cerevisiae, alpha-isopropylmalate (alpha-IPM), which is produced in mitochondria, must be exported to the cytosol where it is required for leucine biosynthesis. Recombinant and reconstituted mitochondrial oxalacetate carrier (Oac1p) efficient... |
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Detection of leucine-independent DNA site occupancy of the yeast Leu3p transcriptional activator in vivo.
Mol. Cell. Biol. 15(8) , 4021-30, (1995) The product of the Saccharomyces cerevisiae LEU3 gene, Leu3p, is a transcriptional activator which regulates leucine biosynthesis in response to intracellular levels of leucine through the biosynthetic intermediate alpha-isopropylmalate. We devised a novel as... |
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Effect of alpha-isopropylmalate on the synthesis of RNA and protein in Neurospora.
Mol. Gen. Genet. 200(2) , 346-9, (1985) The leu-3/alpha-IPM (alpha-isopropylmalate) regulatory system, previously shown to control several genes of leucine, isoleucine, valine, and histidine biosynthesis, appears likely to be involved also in the regulation of overall RNA and protein synthesis in N... |
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Kinetic evidence for interdomain communication in the allosteric regulation of alpha-isopropylmalate synthase from Mycobacterium tuberculosis.
Biochemistry 48(9) , 1996-2004, (2009) The enzyme alpha-isopropylmalate synthase from Mycobacterium tuberculosis (MtIPMS) has been identified as a possible target for the design of new antitubercular therapeutics. Recently, it was shown that MtIPMS is subject to slow-onset, feedback inhibition by ... |
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Synthesis of alpha-isopropylmalate, beta-isopropylmalate, and dimethylcitraconate.
Meth. Enzymol. 166 , 92-6, (1988)
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The role of glutamate 87 in the kinetic mechanism of Thermus thermophilus isopropylmalate dehydrogenase.
Protein Sci. 4(10) , 2156-67, (1995) The kinetic mechanism of the oxidative decarboxylation of 2R,3S-isopropylmalate by the NAD-dependent isopropylmalate dehydrogenase of Thermus thermophilus was investigated. Initial rate results typical of random or steady-state ordered sequential mechanisms a... |
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Regulation of transcription in mammalian cells by yeast Leu3p and externally supplied inducer.
FEBS Lett. 390(2) , 191-5, (1996) The Leu3 protein of yeast is a dual-function regulator, stimulating transcription when the inducer alpha-isopropylmalate (alpha-IPM) is present and suppressing transcription when the inducer is absent. Here we show that Leu3p retains both its positive and neg... |