H-Leu-CMK.HCl
H-Leu-CMK.HCl结构式
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常用名 | H-Leu-CMK.HCl | 英文名 | H-Leu-CMK.HCl |
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| CAS号 | 54518-92-2 | 分子量 | 200.10600 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C7H15Cl2NO | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Acylpeptide hydrolase: inhibitors and some active site residues of the human enzyme.
J. Biol. Chem. 267 , 3811-3818, (1992) Acylpeptide hydrolase may be involved in N-terminal deacetylation of nascent polypeptide chains and of bioactive peptides. The activity of this enzyme from human erythrocytes is sensitive to anions such as chloride, nitrate, and fluoride. Furthermore, blocked... |
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Acetylleucine chloromethyl ketone, an inhibitor of acylpeptide hydrolase, induces apoptosis of U937 cells.
Biochem. Biophys. Res. Commun. 263 , 139-142, (1999) Acetylleucine chloromethyl ketone (ALCK), an inhibitor of acylpeptide hydrolase (ACPH), inhibited the growth of human monoblastic U937 cells in a dose- and time-dependent manner. Morphology of the ALCK-exposed cells showed typical apoptosis, judging from the ... |
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Chloromethyl ketones are insulin-like stimulators of lipid synthesis in locust fat body.
Arch. Insect Biochem. Physiol. 39 , 9-17, (1998) N alpha-tosyl-L-lysine chloromethyl ketone (TLCK) stimulates lipid synthesis in locust fat body in vitro, and is able to reverse the inhibitory effects of AKH-I on lipid synthesis. Effective stimulatory concentrations of TLCK were in the range of 0.2-1.0 mM. ... |
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Metabolism and degradation products of recombinant human insulin-like growth factor-I in lysosomes of rat kidney.
Xenobiotica 29 , 281-295, (1999) 1. The degradation of recombinant human insulin-like growth factor-I (rhIGF-I) by purified lysosomes of rat kidney was examined in vitro. The peptide structures of the 13 degradation products were deduced from the sequence analysis and the molecular mass. Rat... |
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Inhibition of S37 ascites cell amino acid transport systems by alpha-chloromethylketone analogs.
Biochim. Biophys. Acta 601(3) , 640-53, (1980) Alanine chloromethylketone and leucine chloromethylketone were synthesized and their effects on amino acid transport in sarcoma 37 mirone ascites tumor (S37) cells were studied. Alanine chloromethylketone preincubation weakly inhibited system A. Leucine chlor... |
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[14C]leucine chloromethylketone interaction with sarcoma 37 cell plasma membrane components.
Cancer Lett. 16(2) , 207-18, (1982) Leucine chloromethylketone labeling of viable S37 cells was preferential for the plasma membrane fraction. The pattern of radiolabeling of the plasma membrane proteins was time dependent. After 5 min the radiolabel was localized with glutamyl transpeptidase, ... |